Supervised risk predictor of breast cancer based on intrinsic subtypes.
- J. Parker, Michael Mullins, P. Bernard
- Medicine, BiologyJournal of Clinical Oncology
- 10 March 2009
D diagnosis by intrinsic subtype adds significant prognostic and predictive information to standard parameters for patients with breast cancer.
Integrated genomic characterization of endometrial carcinoma
- D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, H. Sofia
- Biology, MedicineNature
- 1 May 2013
The genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours, and these features are classified into four categories: POLE ultramutated, microsatellite instability hypermutated, copy- number low, and copy-number high.
Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
It is confirmed that a prognostically relevant differentiation hierarchy exists across all breast cancers in which the claudin-low subtype most closely resembles the mammary epithelial stem cell.
The Immune Landscape of Cancer
- V. Thorsson, David L. Gibbs, V. Jakrot
- BiologyImmunity
- 1 April 2018
Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer
- M. Cheang, S. Chia, T. Nielsen
- Medicine, BiologyJournal of the National Cancer Institute
- 20 May 2009
Luminal B and luminal–HER2-positive breast cancers were statistically significantly associated with poor breast cancer recurrence-free and disease-specific survival in all adjuvant systemic treatment categories.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
- G. Ciriello, M. Gatza, E. Zmuda
- BiologyCell
- 8 October 2015
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
- D. Brat, R. Verhaak, Jianan Zhang
- MedicineNew England Journal of Medicine
- 25 June 2015
The integration of genomewide data from multiple platforms delineated three molecular classes of lower-grade gliomas that were more concordant with IDH, 1p/19q, and TP53 status than with histologic class.
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma
- M. Ceccarelli, F. Barthel, E. Zmuda
- Biology, MedicineCell
- 28 January 2016
Comprehensive genomic characterization of head and neck squamous cell carcinomas
- M. Lawrence, C. Sougnez, M. Pham
- Biology, MedicineNature
- 28 January 2015
It is shown that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1.
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