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Dyrk1A Phosphorylates p53 and Inhibits Proliferation of Embryonic Neuronal Cells*
Down syndrome (DS) is associated with many neural defects, including reduced brain size and impaired neuronal proliferation, highly contributing to the mental retardation. Those typicalExpand
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  • Open Access
Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1.
The most common genetic disorder Down syndrome (DS) displays various developmental defects including mental retardation, learning and memory deficit, the early onset of Alzheimer's disease (AD),Expand
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  • Open Access
Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome
Down syndrome (DS) is the most common genetic disorder, characterized by mental retardation, congenital heart abnormalities, and susceptibility to Alzheimer's disease (AD). Brain development of DSExpand
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New Perspectives of Dyrk1A Role in Neurogenesis and Neuropathologic Features of Down Syndrome
Down syndrome (DS) is one of the most common genetic disorders accompanying with mental retardation, cognitive impairment, and deficits in learning and memory. The brains with DS also display manyExpand
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  • Open Access
Function and regulation of Dyrk1A: towards understanding Down syndrome
Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating mental retardation and neurodegeneration (i.e., Alzheimer’s disease), that prevent patients from leading fullyExpand
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ASK1 Negatively Regulates the 26 S Proteasome*♦
  • J. Um, E. Im, +5 authors K. Chung
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 15 September 2010
The 26 S proteasome, composed of the 20 S core and 19 S regulatory particle, plays a central role in ubiquitin-dependent proteolysis. Disruption of this process contributes to the pathogenesis of theExpand
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CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory
Protein phosphorylation is an essential step for the expression of long-term potentiation (LTP), a long-lasting, activity-dependent strengthening of synaptic transmission widely regarded as aExpand
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NF-κB-inducing Kinase Phosphorylates and Blocks the Degradation of Down Syndrome Candidate Region 1*
Down syndrome, the most frequent genetic disorder, is characterized by an extra copy of all or part of chromosome 21. Down syndrome candidate region 1 (DSCR1) gene, which is located on chromosome 21,Expand
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Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP
Neural Wiskott–Aldrich syndrome protein (N-WASP) is involved in tight regulation of actin polymerization and dynamics. N-WASP activity is regulated by intramolecular interaction, binding to smallExpand
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Down syndrome critical region 2 protein inhibits the transcriptional activity of peroxisome proliferator-activated receptor beta in HEK293 cells.
Down syndrome is mainly caused by a trisomy of chromosome 21. The Down syndrome critical region 2 (DSCR2) gene is located within a part of chromosome 21, the Down syndrome critical region (DSCR). ToExpand
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