• Publications
  • Influence
Genetic and Clonal Dissection of Murine Small Cell Lung Carcinoma Progression by Genome Sequencing
Small cell lung carcinoma (SCLC) is a highly lethal, smoking-associated cancer with few known targetable genetic alterations. Using genome sequencing, we characterized the somatic evolution of aExpand
  • 182
  • 9
Causal biological network database: a comprehensive platform of causal biological network models focused on the pulmonary and vascular systems
TLDR
We developed a set of biological network models, scripted in the Biological Expression Language, that reflect causal signaling pathways across a wide range of biological processes, including cell fate, cell stress, cell proliferation, inflammation, tissue repair and angiogenesis in the pulmonary and cardiovascular context. Expand
  • 84
  • 3
  • PDF
Antibody-targeted myofibroblast apoptosis reduces fibrosis during sustained liver injury.
BACKGROUND/AIMS Myofibroblast apoptosis promotes the resolution of liver fibrosis. However, retaining macrophages may enhance reversal. The effects of specifically stimulating myofibroblast apoptosisExpand
  • 78
  • 2
  • PDF
Faithful realizability of tropical curves
We study whether a given tropical curve $\Gamma$ in $\mathbb{R}^n$ can be realized as the tropicalization of an algebraic curve whose non-archimedean skeleton is faithfully represented by $\Gamma$.Expand
  • 20
  • 2
  • PDF
Effective Chabauty for symmetric powers of curves
Faltings' theorem states that curves of genus $g \geq 2$ have finitely many rational points. Using the ideas of Faltings, Mumford, Parshin and Raynaud, one obtains an upper bound on the number ofExpand
  • 8
  • 2
  • PDF
Qdot nanobarcodes for multiplexed gene expression analysis.
We report a quantum dot (Qdot) nanobarcode-based microbead random array platform for accurate and reproducible gene expression profiling in a high-throughput and multiplexed format. Four differentExpand
  • 135
  • 1
A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue
TLDR
We have built a detailed network model that captures the biology underlying the physiological cellular response to endogenous and exogenous stressors in non-diseased mammalian pulmonary and cardiovascular cells. Expand
  • 76
  • 1
Enhancement of COPD biological networks using a web-based collaboration interface
The construction and application of biological network models is an approach that offers a holistic way to understand biological processes involved in disease. Chronic obstructive pulmonary diseaseExpand
  • 16
  • 1
  • PDF
Relation of Kinetic Energy to Contact Wounds of the Head by Centerfire Rifles and Shotgun Slugs
Wounds of high‐energy centerfire rifles and shotguns represent distinctive injuries of forensic importance. Previous studies of contact wounds have shown variability in the potential of these weaponsExpand
  • 3
  • 1
A heuristic for boundedness of ranks of elliptic curves
We present a heuristic that suggests that ranks of elliptic curves over the rationals are bounded. In fact, it suggests that there are only finitely many elliptic curves of rank greater than 21. OurExpand
  • 41
  • 1
  • PDF
...
1
2
3
4
5
...