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DNMT3B polymorphisms and risk of primary lung cancer.
DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis. Polymorphisms and haplotypes of the DNMT3B gene may influence DNMT3B activity on… Expand
Polymorphisms in the survivin gene and the risk of lung cancer.
BACKGROUND Survivin is an apoptosis inhibitor and plays an important role in the development and progression of cancer. Polymorphisms in the survivin gene may influence survivin production or… Expand
The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia
Genome-wide association studies of lung cancer reported in populations of European background have identified three regions on chromosomes 5p15.33, 6p21.33, and 15q25 that have achieved genome-wide… Expand
Vascular Endothelial Growth Factor Gene Polymorphisms and Risk of Primary Lung Cancer
- S. Lee, S. Y. Lee, +13 authors J. Park
- Cancer Epidemiology Biomarkers & Prevention
- 1 March 2005
Angiogenesis is an essential process in the development, growth, and metastasis of malignant tumors including lung cancer. DNA sequence variations in the vascular endothelial growth factor (VEGF)… Expand
Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer.
- J. Park, S. Park, +9 authors Tae Hoon Jung
- Cancer epidemiology, biomarkers & prevention : a…
- 1 October 2002
Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may influence an individual's susceptibility to smoking-related cancer. We investigated… Expand
Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer.
DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the… Expand
Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer
Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis and lymphatic tumor spread, thereby affecting prognosis of colorectal… Expand
Polymorphism of the DNA repair gene XRCC1 and risk of primary lung cancer.
DNA repair plays a critical role in protecting the genome of the cell from insults of cancer-causing agents, such as those found in tobacco smoke. Reduced DNA repair capacity, therefore, can increase… Expand
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
To identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned… Expand
MDM2 309T>G polymorphism and risk of lung cancer in a Korean population.
BACKGROUND The MDM2 protein plays an important role in regulating cell proliferation and apoptosis by interaction with multiple proteins including p53 and Rb. A polymorphism (309T>G) in the MDM2… Expand