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FOG2 Protein Down-regulation by Transforming Growth Factor-β1-induced MicroRNA-200b/c Leads to Akt Kinase Activation and Glomerular Mesangial Hypertrophy Related to Diabetic Nephropathy*
Background: The mechanism of TGF-β1-induced Akt kinase activation in diabetic nephropathy (DN) is not fully elucidated. Results: FOG2 down-regulation by TGF-β1-induced miR-200b/c activates Akt, whichExpand
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Renal outcomes in patients with type 2 diabetes with or without coexisting non-diabetic renal disease.
AIMS We sought not only to determine the independent predictors of non-diabetic renal disease (NDRD) but also to investigate the impact of NDRD on renal outcomes in patients with type 2 diabetes whoExpand
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Preservation of renal function by thyroid hormone replacement therapy in chronic kidney disease patients with subclinical hypothyroidism.
CONTEXT Subclinical hypothyroidism is not a rare condition, but the use of thyroid hormone to treat subclinical hypothyroidism is an issue of debate. OBJECTIVE This study was undertaken toExpand
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Repression of let-7 by transforming growth factor-β1-induced Lin28 upregulates collagen expression in glomerular mesangial cells under diabetic conditions.
Accumulation of mesangial extracellular matrix (ECM) proteins such as collagen type 1-α2 (Col1a2) and collagen type 4-α1 (Col4a1) is a key feature of diabetic nephropathy (DN). Transforming growthExpand
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An Increase in Mean Platelet Volume from Baseline Is Associated with Mortality in Patients with Severe Sepsis or Septic Shock
INTRODUCTION Mean platelet volume (MPV) is suggested as an index of inflammation, disease activity, and anti-inflammatory treatment efficacy in chronic inflammatory disorders; however, the effect ofExpand
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PGC-1α Protects from Notch-Induced Kidney Fibrosis Development.
Kidney fibrosis is the histologic manifestation of CKD. Sustained activation of developmental pathways, such as Notch, in tubule epithelial cells has been shown to have a key role in fibrosisExpand
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Obesity, Metabolic Abnormality, and Progression of CKD.
RATIONALE & OBJECTIVE Recent studies have yielded conflicting findings on the association between obesity and progression of chronic kidney disease (CKD). Few studies have evaluated whether metabolicExpand
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TGF-β Induces Acetylation of Chromatin and of Ets-1 to Alleviate Repression of miR-192 in Diabetic Nephropathy
Acetylation of chromatin and Ets-1 contributes to induction of miR-192, a microRNA involved in kidney pathogenesis. Kidney Fibrosis Through Acetylation Epigenetic changes alter gene expression andExpand
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Thyroid hormone replacement therapy attenuates the decline of renal function in chronic kidney disease patients with subclinical hypothyroidism.
BACKGROUND Subclinical hypothyroidism (SCH) is not a rare condition in females, the elderly, or patients with chronic kidney disease (CKD). Even though previous studies have demonstrated that thyroidExpand
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Uric acid is associated with the rate of residual renal function decline in peritoneal dialysis patients.
BACKGROUND Uric acid (UA) is known to play a pathogenic role in chronic kidney disease (CKD). However, its effect in end-stage renal disease (ESRD) has not yet been elucidated. We explored theExpand
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