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Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
TLDR
At a given time point of the disease, the patterns of demyelination were heterogeneous between patients, but were homogenous within multiple active lesions from the same patient, suggesting that MS may be a disease with heterogeneous pathogenetic mechanisms. Expand
Cortical demyelination and diffuse white matter injury in multiple sclerosis.
TLDR
Global brain pathology in multiple sclerosis is analysed, focusing on the normal-appearing white matter (NAWM) and the cortex, to suggest that multiple sclerosis starts as a focal inflammatory disease of the CNS, which gives rise to circumscribed demyelinated plaques in the white matter. Expand
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
TLDR
PCA is a distinctive dementia syndrome in which the most pronounced pathologic involvement is in the occipitoparietal regions independent of the specific underlying pathology. Expand
A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica.
TLDR
The extent of complement activation, eosinophilic infiltration and vascular fibrosis observed in the Devic NMO cases is more prominent compared with that in prototypic multiple sclerosis, and supports a role for humoral immunity in the pathogenesis of NMO. Expand
Common variants in MS4A4/MS4A6E, CD2uAP, CD33, and EPHA1 are associated with late-onset Alzheimer’s disease
The Alzheimer Disease Genetics Consortium (ADGC) performed a genome-wide association study of late-onset Alzheimer disease using a three-stage design consisting of a discovery stage (stage 1) and twoExpand
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease.
TLDR
The data suggest that many patients with 'idiopathic' RBD are actually exhibiting an early clinical manifestation of an evolving neurodegenerative disorder, and may be appropriate for future drug therapies that affect synuclein pathophysiology, in which the development of parkinsonism and/or dementia could be delayed or prevented. Expand
Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis
TLDR
Although lesion size >5 cm was associated with a slightly higher EDSS at last follow-up, long-term prognosis in patients with disease duration >10 years was better compared with a population-based multiple sclerosis cohort matched for disease duration (EDSS 3.5; P < 0.001). Expand
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
TLDR
It is suggested that neuronal loss in association areas such as the superior temporal sulcus contributes directly to cognitive impairment in AD. Expand
Clinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP
TLDR
Frontotemporal lobar degeneration, corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP) have overlapping clinical features, and the prediction of tau-positive pathology from a CBD or PSP-like presentation is good, while the frontotem temporal dementia (FTD)-motor neuron disease syndrome almost certainly predicts motor neuron degeneration. Expand
Increased risk of type 2 diabetes in Alzheimer disease.
TLDR
The hypothesis that patients with Alzheimer disease are more vulnerable to type 2 diabetes and the possibility of linkage between the processes responsible for loss of brain cells and beta-cells in these diseases are supported. Expand
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