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The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis.
Crohn's disease is a lifelong disease arising from an interaction between genetic and environmental factors, but observed predominantly in developed countries of the world. The precise aetiology isExpand
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Randomized comparative study of therapeutic paracentesis with and without intravenous albumin in cirrhosis.
It has recently been shown that repeated large-volume paracentesis associated with intravenous albumin infusion is a rapid, effective, and safe therapy of ascites in cirrhosis. To investigate whetherExpand
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Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 3: special situations.
### 8.1 General Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the procedure of choice for most patients with ulcerative colitis (UC) requiring colectomy.1 Pouchitis is a non-specificExpand
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Tofacitinib as Induction and Maintenance Therapy for Ulcerative Colitis.
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Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis.
BACKGROUND Ulcerative colitis is a chronic inflammatory disease of the colon for which current treatments are not universally effective. One additional treatment may be tofacitinib (CP-690,550), anExpand
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Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial
BACKGROUND Etrolizumab is a humanised monoclonal antibody that selectively binds the β7 subunit of the heterodimeric integrins α4β7 and αEβ7. We aimed to assess etrolizumab in patients withExpand
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Neutrophil Infiltration Increases Matrix Metalloproteinase-9 in the Ischemic Brain after Occlusion/Reperfusion of the Middle Cerebral Artery in Rats
Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during the first day after focal ischemia and might be involved in the pathogenesis of tissue damage. We previously showed MMP-9 inExpand
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Loss of Response and Requirement of Infliximab Dose Intensification in Crohn's Disease: A Review
OBJECTIVES:To review the frequency with which infliximabloses its effect and dose “intensification” is required for Crohn's disease treatment.METHODS:Bibliographical searches were performed inExpand
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Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease.
Leukocyte-endothelial cell adhesion is now recognized to represent an early and rate-limiting step in the leukocyte infiltration and accompanying tissue injury that is associated with acute andExpand
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Leukocyte‐endothelial cell adhesion: avenues for therapeutic intervention
British Journal of Pharmacology (1999) 126, 537–550; doi:10.1038/sj.bjp.0702328
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