Characterization of the imitation switch subfamily of ATP-dependent chromatin-remodeling factors in Saccharomyces cerevisiae.
- T. Tsukiyama, J. Palmer, C. Landel, J. Shiloach, C. Wu
- BiologyGenes & Development
- 15 March 1999
It is demonstrated that the ATP-dependent chromatin-remodeling activities are essential for the in vivo functions of both ISW1 and ISW2 complexes.
Distinct Regions of the Large Extracellular Domain of Tetraspanin CD9 Are Involved in the Control of Human Multinucleated Giant Cell Formation
- Rachel S. Hulme, A. Higginbottom, J. Palmer, L. Partridge, P. Monk
- BiologyPLoS ONE
- 31 December 2014
Two spatially-distinct sites on the CD9 EC2 that are required for inhibitory activity are defined and agents that target these sites could have therapeutic applications in diseases in which multinucleated giant cells play a pathogenic role.
Phylogenetic measures of indel rate variation among the HIV-1 group M subtypes
Indel rates were significantly lower in the region encoding variable loop V3, and also lower for HIV-1 subtype B relative to other subtypes, and it was found that variable loops V1, V2 and V4 tended to accumulate significantly longer indels.
Phylogenetic measures of indel rate variation among the HIV-1 group M subtypes.
This work develops and reports results from a phylogenetic method to estimate indel rates for the gp120 variable regions across five major subtypes and two circulating recombinant forms (CRFs) of HIV-1 group M, and identifies novel and unexpected patterns for further research in the molecular evolution of HIV.
A Ruthenium(II) Polypyridyl Complex Disrupts Actin Cytoskeleton Assembly and Blocks Cytokinesis
- Martin R. Gill, Paul J Jarman, C. Smythe
- ChemistryAngewandte Chemie
- 13 April 2022
Investigation of the dinuclear Ru(II) complex reveals that addition of RuRuPhen causes rapid disruption to actin stress fibre organisation, compromising actomyosin contractility and cell motility, and causes cytokinetic abscission failure by interfering with ESCRT complex recruitment.
Recombinant expression and analysis of tetraspanin extracellular-2 domains
- J. Palmer
- 17 February 2016
Recruitment of recombinant EC2 domains of tetraspanins CD9, CD63, CD81 and CD151 were used for the first time in conjunction with RBL-2H3 cells to examine t Petraspanin involvement in IgE mediated degranulation and results gave inconclusive results.
Phylogenetic estimates of HIV-1 gp120 indel rates across the group M subtypes
Faculty Opinions recommendation of A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.
- K. Ayscough, J. Palmer, E. Allwood
- EngineeringFaculty Opinions – Post-Publication Peer Review…
- 25 January 2019