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Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo.
BACKGROUND/AIMS Intense pruritus and the risk of stillbirths and premature deliveries justify the search for an effective pharmacologic treatment of intrahepatic cholestasis of pregnancy. This studyExpand
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Selenium, zinc and copper plasma levels in intrahepatic cholestasis of pregnancy, in normal pregnancies and in healthy individuals, in Chile.
BACKGROUND/AIMS Low blood Se levels have been previously shown in normal pregnancies (third trimester) and significantly lower levels in patients with intrahepatic cholestasis of pregnancy (ICP), inExpand
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An Independent Interobserver Reliability and Intraobserver Reproducibility Evaluation of the New AOSpine Thoracolumbar Spine Injury Classification System
Study Design. Agreement study. Objective. To perform an independent interobserver and intraobserver agreement evaluation of the new AOSpine Thoracolumbar Spine Injury Classification System. SummaryExpand
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Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy
The efficacy and safety of ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy was investigated in an open pilot study. Five patients received 1 gm/day of ursodeoxycholicExpand
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Ursodeoxycholic acid in the treatment of intrahepatic cholestasis of pregnancy.
Abstract: Objective: To assess the efficacy of ursodeoxycholic acid (UDCA) in patients with intrahepatic cholestasis of pregnancy (ICP) and in the outcome of pregnancy.
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Profiles of bile acids and progesterone metabolites in the urine and serum of women with intrahepatic cholestasis of pregnancy.
BACKGROUND/AIMS AND METHODS The etiology of intrahepatic cholestasis of pregnancy (JCP) is unknown. We have performed comprehensive chromatographic and mass spectrometric analyses of progesteroneExpand
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Progesterone metabolites and bile acids in serum of patients with intrahepatic cholestasis of pregnancy: Effect of ursodeoxycholic acid therapy
The concentrations in serum of sulfated metabolites of progesterone are known to be elevated in patients with intrahepatic cholestasis of pregnancy (ICP). The profiles of these metabolites andExpand
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Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy.
BACKGROUND/AIMS AND METHODS The mechanism(s) behind the effects of ursodeoxycholic acid on serum steroid sulphate profiles in patients with intrahepatic cholestasis of pregnancy is not clear.Expand
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Treatment of metastatic Ewing's sarcoma with BCNU
Twelve patients with metastatic Ewing's sarcoma, ranging in age from 4 to 26 years, were treated with 1‐3‐bis chloroethyl nitrosourea (BCNU). The tumor in five of the patients showed objective tumorExpand
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Is a leaky gut involved in the pathogenesis of intrahepatic cholestasis of pregnancy?
Increased gastrointestinal permeability has been demonstrated in several liver diseases. It may facilitate the absorption of gut‐derived endotoxin‐stimulating Kupffer cells to release proinflammatoryExpand
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