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gp25L/emp24/p24 Protein Family Members of the cis-Golgi Network Bind Both COP I and II Coatomer
Abstract. Five mammalian members of the gp25L/ emp24/p24 family have been identified as major constituents of the cis-Golgi network of rat liver and HeLa cells. Two of these were also found inExpand
Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum
Sec24 of the COPII (coat protein complex II) vesicle coat mediates the selective export of membrane proteins from the endoplasmic reticulum (ER) in yeast. Human cells express four Sec24 isoforms, butExpand
COPI-coated ER-to-Golgi transport complexes segregate from COPII in close proximity to ER exit sites.
Transport of proteins between the endoplasmic reticulum and Golgi apparatus is mediated by two distinct membrane coat complexes, COPI and COPII. Genetic, biochemical and morphological data haveExpand
Selective export of human GPI-anchored proteins from the endoplasmic reticulum
Selective export of transmembrane proteins from the endoplasmic reticulum (ER) relies on recognition of cytosolic-domain-localized transport signals by the Sec24 subunit of the COPII vesicle coat.Expand
PSA‐NCAM modulates BDNF‐dependent survival and differentiation of cortical neurons
We show that the loss or inactivation of the polysialic acid (PSA) tail of neural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. TheExpand
The Recycling of ERGIC-53 in the Early Secretory Pathway
Further investigation of the targeting of the intracellular membrane lectin endoplasmic reticulum (ER)-Golgi intermediate compartment-53 (ERGIC-53) by site-directed mutagenesis revealed that itsExpand
Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export.
Export of membrane proteins from the ER is believed to be selective and require transport signals, but the identity of such signals has remained elusive. The recycling type I membrane proteinExpand
Cloning and functional characterization of mammalian homologues of the COPII component Sec23.
We screened a human cDNA library with a probe derived from a partial SEC23 mouse homologue and isolated two different cDNA clones (hSec23A and hSec23B) encoding proteins of a predicted molecular massExpand
Sec24 Proteins and Sorting at the Endoplasmic Reticulum*
COPII proteins are necessary to generate secretory vesicles at the endoplasmic reticulum. In yeast, the Sec24p protein is the only COPII component in which two close orthologues have been identified.Expand
Evidence for Prebudding Arrest of ER Export in Animal Cell Mitosis and its Role in Generating Golgi Partitioning Intermediates
During mitosis the interconnected Golgi complex of animal cells breaks down to produce both finely dispersed elements and discrete vesiculotubular structures. The endoplasmic reticulum (ER) plays aExpand