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Electrophysiological effects of S 16257, a novel sino‐atrial node modulator, on rabbit and guinea‐pig cardiac preparations: comparison with UL‐FS 49
1 S 16257 is a new bradycardic agent. Its electropharmacological profile has been compared to that of the known bradycardic compound UL‐FS 49 (Zatebradine). Intracellular recordings of actionExpand
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Cannabinoid CB1 receptor and endothelium‐dependent hyperpolarization in guinea‐pig carotid, rat mesenteric and porcine coronary arteries
1 The purpose of these experiments was to determine whether or not the endothelium‐dependent hyperpolarizations of the vascular smooth muscle cells (observed in the presence of inhibitors of nitricExpand
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Potassium ions and endothelium‐derived hyperpolarizing factor in guinea‐pig carotid and porcine coronary arteries
Experiments were designed to determine in two arteries (the guinea‐pig carotid and the porcine coronary arteries) whether or not the endothelium‐derived hyperpolarizing factor (EDHF) can beExpand
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Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.
The role of angiotensin receptor subtypes 1 and 2 was assessed on neointima formation after injury in rat carotid artery. The effects of angiotensin converting enzyme inhibition by perindopril (3Expand
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Stereospecific in vitro and in vivo effects of the new sinus node inhibitor (+)-S 16257.
The effects of the two isomers, (+)-S 16257 and (-)-S 16260, of a new bradycardic agent, (+/-)-S 15544 (7,8-dimethoxy 3-[3-[[(4.5-dimethoxybenzocyclobutan-1-yl)methyl]Expand
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Angiotensin I-converting enzyme genotype influences arterial response to injury in normotensive rats.
Two normotensive strains of rat, the Lou and Brown Norway (BN) strains, have contrasting levels of plasma angiotensin-converting enzyme (ACE). To investigate the degree of genetic determination ofExpand
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Nature of the cardiomyocyte injury induced by lipid hydroperoxides.
OBJECTIVE As a result of oxidative stress to membrane lipid matrix, the peroxidation of polyunsaturated fatty acids induced the transient formation of lipid hydroperoxides (ROOH). The aim of thisExpand
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Effects of altered site of electrical activation on myocardial performance during inotropic stimulation.
The effects of altering the site of electrical activation on responses to isoproterenol (ISO) and treadmill exercise were examined in mongrel dogs instrumented for long-term measurement of leftExpand
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Role of Prejunctional α2‐Adrenergic Receptors in the Regulation of Myocardial Performance during Exercise in Conscious Dogs
We examined, in conscious dogs, the potential role of prejunctional a2-adrenergic receptors for the regulation of heart rate and contractility response to exercise through modulation of theExpand
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Monohydroperoxidized fatty acids but not 4-hydroxynonenal induced acute cardiac cell damage.
Unsaturated fatty acids constitutive of cardiac membranal lipid matrix are one of the primary targets for reactive oxygen species generated during ischemia-reperfusion cycle. Lipid peroxidation is aExpand
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