• Publications
  • Influence
The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
This review aims to give a brief overview of NPY receptor distribution and physiology in the brain and summarizes series of studies, test by test and region by region, aimed at identificationExpand
  • 300
  • 17
Partial role of 5-HT2 and 5-HT3 receptors in the activity of antidepressants in the mouse forced swimming test.
The present study was designed to evaluate the roles of 5-HT2 and 5-HT3 receptors in the mouse forced swimming test, by using selective agonists and antagonists of 5-HT(2A/C) and 5-HT3 receptorExpand
  • 156
  • 17
Dose-dependent noradrenergic and serotonergic properties of venlafaxine in animal models indicative of antidepressant activity
Abstract The present study was undertaken to investigate thoroughly the preclinical psychopharmacological profile of venlafaxine, testing a wide range of doses in animal models indicative ofExpand
  • 156
  • 10
The Neuropeptide Y (NPY) Y1 Receptor Subtype Mediates NPY-induced Antidepressant-like Activity in the Mouse Forced Swimming Test
The present study was undertaken to investigate the possible antidepressant-like effects of neuropeptide Y (NPY) in the mouse forced swimming test, an animal model widely used for the screening ofExpand
  • 179
  • 8
Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition
Neuropeptide Y (NPY) is widely distributed throughout the central nervous system (CNS) and is one of the most conserved peptides in evolution, suggesting an important role in the regulation of basicExpand
  • 145
  • 7
Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats
RationaleA growing body of evidence suggests that negative modulation of γ-aminobutyric acid (GABA) GABAA α5 receptors may be a promising strategy for the treatment of certain facets of cognitiveExpand
  • 53
  • 6
The role of 5-HT1A and 5-HT1B receptors in antidepressant drug actions in the mouse forced swimming test.
The forced swimming test is a behavioural model developed to predict the efficacy of antidepressant drugs. Few studies have been aimed at evaluating the mechanism of action of antidepressants in theExpand
  • 125
  • 5
Neuropeptide Y (NPY) Y2 receptors mediate behaviour in two animal models of anxiety: evidence from Y2 receptor knockout mice
The behavioural phenotype of mice lacking neuropeptide Y (NPY) Y(2)-type receptors was assessed in two well documented animal models of anxiety: namely, the elevated plus maze and the open field. NPYExpand
  • 118
  • 5
Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex
Clinical and preclinical evidence suggest a role of nicotinic acetylcholine receptors in major depression. In humans, both nicotine and the nonselective nicotinic acetylcholine receptor antagonistExpand
  • 63
  • 5
Neuropeptide Y and Its Receptor Subtypes in the Central Nervous System: Emphasis on Their Role in Animal Models of Psychiatric Disorders
In this chapter, we briefly review the pharmacology and distribution of the neuropeptide Y (NPY) Y1, Y2, Y4 Y5, and y6 receptor proteins and mRNAs. NPY and its receptors are widely distributed in theExpand
  • 17
  • 5