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The pharmacokinetics of cefotaxime and its metabolites in subjects with normal and impaired renal function.
The pharmacokinetics of single doses (15 mg/kg) of cefotaxime and each of its metabolites were examined in six normal subjects and 24 patients who showed various degrees of renal insufficiency. AnExpand
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Pharmacokinetics of meropenem (ICI 194,660) and its metabolite (ICI 213,689) in healthy subjects and in patients with renal impairment.
The pharmacokinetics of meropenem (ICI 194,660) and its open-ring metabolite (ICI 213,689) were studied in 6 healthy volunteers and 16 patients with moderate to severe renal impairment after a singleExpand
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Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas.
We retrospectively analyzed clinical presentation, immunopathological data and renal outcome in 13 patients with glomerulonephritis (GN) and chronic lymphocytic leukemia (CLL) or related diffuseExpand
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Zidovudine disposition in patients with severe renal impairment: Influence of hemodialysis
Pharmacokinetics of zidovudine (azidothymidine, AZT) was investigated after oral administration (200 mg) in 25 HIV seronegative subjects: 14 patients with severe renal impairment (creatinineExpand
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Prediction of creatinine clearance from serum creatinine concentration based on lean body mass
An equation for predicting endogenous creatinine clearance (CrCl) in adults and children (with both stable and unstable renal function) from serum creatinine concentrations is presented. TheExpand
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Comparative pharmacokinetics of tromethamine fosfomycin and calcium fosfomycin in young and elderly adults.
The pharmacokinetics of two oral forms of fosfomycin, tromethamine (trometamol) salt and calcium salt, were studied in five young (age, 29 +/- 3 [standard deviation] years) and eight elderly (age, 72Expand
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[Rilmenidine, a new antihypertensive agent in the first line treatment of essential arterial hypertension. Multicenter double-blind study versus atenolol].
After 4 weeks on placebo, 90 hypertensive patients (37 men, 53 women, mean age 55 years) with systolic (SBP) and diastolic (DBP) blood pressures of 162/99 and 165/100 mmHg respectively receivedExpand
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Biochemical, functional, and morphological characterization of a primary culture of rabbit proximal tubule cells.
Primary cultures of renal rabbit proximal tubule cells were initiated from a pure suspension of proximal tubule fragments. Proximal tubule cells were grown in a hormone-supplemented, serum-freeExpand
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Altered flow-dependent vasodilatation of conduit arteries in maintenance haemodialysis.
BACKGROUND An altered arterial nitric oxide (NO) pathway could partly explain the damage to arteries observed in haemodialyzed (HD) patients. The present study was designed to non-invasively evaluateExpand
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Pharmacokinetics of aminoglycosides in subjects with normal and impaired renal function.
Since aminoglycosides are antibiotics almost exclusively eliminated by the kidneys, their pharmacokinetic study in normal subjects and in uraemic patients is essential to establish dosage schedulesExpand
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