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WNT/Frizzled signalling: receptor–ligand selectivity with focus on FZD‐G protein signalling and its physiological relevance: IUPHAR Review 3
The current understanding of receptor/ligand selectivity of FZDs and WNTs is presented and what is known about signalling specification and the physiological relevance of these interactions are pinpointed with special emphasis on FZD–G protein interactions. Expand
Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs*
Differential WNT-FZD binding and selective functional readouts suggest that endogenous WNT ligands evolved with an intrinsic natural bias toward different downstream signaling pathways, a phenomenon that could be of great importance in the design of FZD-targeting drugs. Expand
The Concise Guide to PHARMACOLOGY 2013/14: Overview
The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of the key properties of over 2000 human drug targets with their pharmacology, plus links to an open access knowledgebase of drugExpand
Sequential Activation and Inactivation of Dishevelled in the Wnt/β-Catenin Pathway by Casein Kinases
A multistep and multikinase model for Dvl activation in the Wnt/β-catenin pathway is proposed that uncovers a built-in de-activation mechanism that is triggered by activating phosphorylation of Dvl by CK1δ/ϵ. Expand
Heterotrimeric G protein-dependent WNT-5A signaling to ERK1/2 mediates distinct aspects of microglia proinflammatory transformation
WNT-5A emerges as an important means of astrocyte-microglia communication and is suggested as a new player in neuroinflammatory conditions, such as neurodegenerative disease, hypoxia, stroke, injury and infection. Expand
CX3CL1--a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle.
It is suggested that CX3CL1 participates in cross-talk mechanisms between endothelium and other muscle tissue cells and may promote a shift in the microenvironment toward a more regenerative milieu. Expand
WNT-5A stimulates the GDP/GTP exchange at pertussis toxin-sensitive heterotrimeric G proteins.
Molecular proof is provided for the first time molecular proof that WNT-5A stimulation results in the activation of heterotrimeric G(i2/3) proteins in mammalian cells with physiological protein stochiometry. Expand
High levels of WNT-5A in human glioma correlate with increased presence of tumor-associated microglia/monocytes.
A positive correlation between WNT-5A and a proinflammatory signature in glioma is pinpointed and increased presence of microglia/monocytes is identified as an important aspect in the inflammatory transformation suggesting a novel role for WNT -5A in human gliomas. Expand
Receptor binding and functional selectivity of WNTs 1 Systematic mapping of WNT-Frizzled interactions reveals functional selectivity by distinct WNT-Frizzled pairs
To whom the correspondence should be addressed: Gunnar Schulte, Section of Receptor Biology & Signaling, Dept. Physiology & Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden. Tel.:Expand
CX 3 CL 1 — a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle
Strömberg A, Olsson K, Dijksterhuis JP, Rullman E, Schulte G, Gustafsson T. CX3CL1—a macrophage chemoattractant induced by a single bout of exercise in human skeletal muscle. Am J Physiol RegulExpand