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Physiological activation of a cortical network during performance of the Wisconsin Card Sorting Test: A positron emission tomography study
TLDR
The WCST activation in the dorsolateral prefrontal cortex (DLPFC) remained significant even after training and practice on the test, suggesting that working memory may be largely responsible for the physiological response in DLPFC during the WCST and, conversely, that the DLP FC plays a major role in modulating working memory. Expand
Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson's disease
TLDR
It is proposed that DBS of the basal ganglia improves cortical function by alleviating excessive beta phase locking of motor cortex neurons. Expand
Exaggerated phase–amplitude coupling in the primary motor cortex in Parkinson disease
TLDR
Analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery prompts a model of the basal ganglia–cortical circuit in Parkinson disease incorporating phase–amplitude interactions and abnormal corticosubthalamic feedback. Expand
Subthalamic Nucleus Neurons Are Synchronized to Primary Motor Cortex Local Field Potentials in Parkinson's Disease
TLDR
In humans undergoing deep brain stimulator implantation surgery, the novel technique of subdural electrocorticography in combination with subthalamic nucleus (STN) single-unit recording is used to study basal ganglia–cortex interactions at the millisecond time scale to support a model of the basalganglia-thalamocortical loop in PD. Expand
Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
TLDR
The initial data support the safety, tolerability, and potential efficacy of CERE-120 as a possible treatment for PD; however, these results must be viewed as preliminary until data from blinded, controlled clinical trials are available. Expand
Spontaneous pallidal neuronal activity in human dystonia: comparison with Parkinson's disease and normal macaque.
TLDR
GPi showed increased oscillatory activity in the 2- to 10-Hz range and increased bursting activity in both dystonia and PD as compared with the normal NHPs, which is most consistent with a model of dystonian pathophysiology in which the two striatal cell populations contributing to the direct and indirect intrinsic pathways of the basal ganglia both have increased spontaneous activity. Expand
Treatment of dystonia with deep brain stimulation
TLDR
Pallidal deep brain stimulation (DBS) is an established treatment option for medically refractive dystonia and the role of GPi DBS in idiopathic cervical dystonIA resistant to treatment with botulinum toxin, in tardive dySTONia, and in some types of secondary dystonian are emerging as populations of patients who may also benefit, but outcomes are not well documented. Expand
Modulation of cognition-specific cortical activity by gonadal steroids: a positron-emission tomography study in women.
TLDR
Data from H215O positron-emission tomography demonstrate that the hormonal milieu modulates cognition-related neural activity in humans during three pharmacologically controlled hormonal conditions spanning 4-5 months. Expand
Subthalamic nucleus deep brain stimulation in primary cervical dystonia
TLDR
Bilateral subthalamic nucleus deep brain stimulation results in significant improvement in cervical dystonia without bradykinetic side effects and suggests that STN DBS may be an alternative to GPi DBS for treating primary cervical dySTONia. Expand
Uncoupling Cognitive Workload and Prefrontal Cortical Physiology: A PET rCBF Study
TLDR
The results suggest that increases in cognitive workload do not necessarily recruit and then sustain cortical neurophysiological resources to a maximum, but rather may actually be accompanied by a diminution in cortical activity. Expand
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