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BIOLOGICAL SCREENING OF CYANOBACTERIA FOR ANTIMICROBIAL AND MOLLUSCICIDAL ACTIVITY, BRINE SHRIMP LETHALITY, AND CYTOTOXICITY
A total of 86 lipophilic and hydrophilic extracts obtained from 43 samples of cultured and field collected freshwater and terrestrial cyanobacteria have been screened for their biological activities.Expand
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Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds and a large number of chemically diverse and bioactive metabolites have been obtained from cyanobacteria over theExpand
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Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune.
Five novel extracellular metabolites with an unprecedented diterpenoid skeleton, 5-[(5-carboxy-2-hydroxy)benzyl]-11-hydroxymethyl-2,5,6,8a, 11-pentamethyldodecahydrocyclopentanaphthalene (1),Expand
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Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp.
Material collected from a parkway in the city of Chicago afforded the isolation of a Nostoc species (UIC 10022A). The extract of this strain displayed significant inhibition of the 20S proteasome asExpand
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Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
Bioactivity-guided fractionation of a CH2Cl2 extract from the leaves of Piper aduncum afforded three new dihydrochalcones, piperaduncins A [3], B [4], and C [5], as well as two knownExpand
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Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.
Five new prenylated benzoic acid derivatives, methyl 3-(3,7-dimethyl-2,6-octadienyl)-4-methoxybenzoate (1), 1-(1-methylethyl)-4-methyl-3-cyclohexenyl 3,5-bis(3-methyl-2-butenyl)-4-hydroxybenzoateExpand
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Short Peptide Induces an “Uncultivable” Microorganism To Grow In Vitro
ABSTRACT Microorganisms comprise the bulk of biodiversity, but only a small fraction of this diversity grows on artificial media. This phenomenon was noticed almost a century ago, repeatedlyExpand
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Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula.
The lipid extract from a Curaçao collection of the marine cyanobacterium Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata. Subsequent bioassay-guided fractionation of this extractExpand
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Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites.
An LC-MS-NMR platform is demonstrated, which combines two innovations in microscale analysis, nanoSplitter LC-MS and microdroplet NMR, for the identification of unknown compounds found at lowExpand
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