Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
BIOLOGICAL SCREENING OF CYANOBACTERIA FOR ANTIMICROBIAL AND MOLLUSCICIDAL ACTIVITY, BRINE SHRIMP LETHALITY, AND CYTOTOXICITY
- B. Jaki, J. Orjala, H. Bürgi, O. Sticher
- Biology
- 1999
A total of 86 lipophilic and hydrophilic extracts obtained from 43 samples of cultured and field collected freshwater and terrestrial cyanobacteria have been screened for their biological activities.… Expand
Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majuscula
- J. Orjala, D. Nagle, V. Hsu, W. H. Gerwick
- Chemistry
- 1 August 1995
Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.
- G. Chlipala, Shunyan Mo, J. Orjala
- Biology, Medicine
- Current drug targets
- 30 September 2011
Cyanobacteria are considered a promising source for new pharmaceutical lead compounds and a large number of chemically diverse and bioactive metabolites have been obtained from cyanobacteria over the… Expand
Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune.
- B. Jaki, J. Orjala, J. Heilmann, A. Linden, B. Vogler, O. Sticher
- Biology, Medicine
- Journal of natural products
- 1 March 2000
Five novel extracellular metabolites with an unprecedented diterpenoid skeleton, 5-[(5-carboxy-2-hydroxy)benzyl]-11-hydroxymethyl-2,5,6,8a, 11-pentamethyldodecahydrocyclopentanaphthalene (1),… Expand
Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp.
- G. Chlipala, M. Sturdy, +5 authors J. Orjala
- Chemistry, Medicine
- Journal of natural products
- 24 September 2010
Material collected from a parkway in the city of Chicago afforded the isolation of a Nostoc species (UIC 10022A). The extract of this strain displayed significant inhibition of the 20S proteasome as… Expand
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
Bioactivity-guided fractionation of a CH2Cl2 extract from the leaves of Piper aduncum afforded three new dihydrochalcones, piperaduncins A [3], B [4], and C [5], as well as two known… Expand
Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.
- J. Orjala, C. Erdelmeier, A. Wright, T. Rali, O. Sticher
- Biology, Medicine
- Planta medica
- 1 December 1993
Five new prenylated benzoic acid derivatives, methyl 3-(3,7-dimethyl-2,6-octadienyl)-4-methoxybenzoate (1), 1-(1-methylethyl)-4-methyl-3-cyclohexenyl 3,5-bis(3-methyl-2-butenyl)-4-hydroxybenzoate… Expand
Short Peptide Induces an “Uncultivable” Microorganism To Grow In Vitro
- D. Nichols, K. Lewis, +7 authors S. Epstein
- Biology, Medicine
- Applied and Environmental Microbiology
- 30 May 2008
ABSTRACT Microorganisms comprise the bulk of biodiversity, but only a small fraction of this diversity grows on artificial media. This phenomenon was noticed almost a century ago, repeatedly… Expand
Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula.
- J. Orjala, W. H. Gerwick
- Biology, Medicine
- Journal of natural products
- 22 April 1996
The lipid extract from a Curaçao collection of the marine cyanobacterium Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata. Subsequent bioassay-guided fractionation of this extract… Expand
Microscale LC-MS-NMR platform applied to the identification of active cyanobacterial metabolites.
- Y. Lin, S. Schiavo, J. Orjala, P. Vouros, R. Kautz
- Chemistry, Medicine
- Analytical chemistry
- 1 November 2008
An LC-MS-NMR platform is demonstrated, which combines two innovations in microscale analysis, nanoSplitter LC-MS and microdroplet NMR, for the identification of unknown compounds found at low… Expand