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BIOLOGICAL SCREENING OF CYANOBACTERIA FOR ANTIMICROBIAL AND MOLLUSCICIDAL ACTIVITY, BRINE SHRIMP LETHALITY, AND CYTOTOXICITY
A total of 86 lipophilic and hydrophilic extracts obtained from 43 samples of cultured and field collected freshwater and terrestrial cyanobacteria have been screened for their biological activities, finding a lethal effect against brine shrimp and a molluscicidal effect against Biomphalaria glabrata.
Cylindrocyclophanes with proteasome inhibitory activity from the Cyanobacterium Nostoc sp.
Material collected from a parkway in the city of Chicago afforded the isolation of a Nostoc species (UIC 10022A). The extract of this strain displayed significant inhibition of the 20S proteasome as…
Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.
Five new prenylated benzoic acid derivatives were isolated from the dried leaves of Piper aduncum L. (Piperaceae) and displayed significant antibacterial activities.
Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.
Bioactivity-guided fractionation of a CH2Cl2 extract from the leaves of Piper aduncum afforded three new dihydrochalcones, piperaduncins A, B, and C, and the proposed stereochemistry for compound 4 was deduced by NOESY spectroscopy and the corresponding energy minimum was established by molecular modelling calculations and translated into 3D structure.
Chemodiversity in freshwater and terrestrial cyanobacteria - a source for drug discovery.
This review highlights the structural diversity of natural products from freshwater and terrestrial cyanobacteria and discusses the potent cytotoxins cryptophycin and tolytoxin.
Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majuscula
Novel extracellular diterpenoids with biological activity from the cyanobacterium Nostoc commune.
- B. Jaki, J. Orjala, J. Heilmann, A. Linden, B. Vogler, O. Sticher
- ChemistryJournal of natural products
- 1 March 2000
Five novel extracellular metabolites with an unprecedented diterpenoid skeleton, comnostins A-E, isolated from the culture medium of the terrestrial cyanobacterium Nostoc commune by means of bioguided isolation showed antibacterial activities.
A novel extracellular diterpenoid with antibacterial activity from the cyanobacterium Nostoc commune.
A novel extracellular metabolite with an unprecedented diterpenoid skeleton, Noscomin, which exhibited antibacterial activity against Bacillus cereus, Staphylococcus epidermidis, and Escherichia coli.
Barbamide, a chlorinated metabolite with molluscicidal activity from the Caribbean cyanobacterium Lyngbya majuscula.
The lipid extract from a Curaçao collection of the marine cyanobacterium Lyngbya majuscula was toxic to the mollusc Biomphalaria glabrata and yielded a novel lipopeptide, barbamide, as the active compound.
Short Peptide Induces an “Uncultivable” Microorganism To Grow In Vitro
Growth induction of MSC33 illustrates that some microorganisms do not grow in vitro because they are removed from their native communities and the signals produced therein, and demonstrates that the restriction preventing microbial in vitro growth may be different from those offered to explain the “great plate count anomaly.