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Mixed linear model approach adapted for genome-wide association studies
TLDR
A compression approach is reported, called 'compressed MLM', that decreases the effective sample size of such datasets by clustering individuals into groups and a complementary approach, 'population parameters previously determined' (P3D), that eliminates the need to re-compute variance components. Expand
Common variants at 30 loci contribute to polygenic dyslipidemia
TLDR
The results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia. Expand
Familial Lipoprotein Disorders in Patients With Premature Coronary Artery Disease
TLDR
It is indicated that more than half of patients with premature CAD have a familial lipoprotein disorder, with Lp(a) excess, hypertriglyceridemia with hypoalphalipoproteinemia, and combined hyperlipidemia and apolipoprotein levels are in part genetically determined. Expand
Epigenetics and cardiovascular disease
TLDR
Epigenomics has emerged as one of the most promising areas that will address some of the gaps in current knowledge of the interaction between nature and nurture in the development of CVD, and may lead to earlier prevention and novel therapy for CVD. Expand
Association of cholesteryl ester transfer protein-TaqIB polymorphism with variations in lipoprotein subclasses and coronary heart disease risk: the Framingham study.
TLDR
Variation at the CETP gene locus is a significant determinant of HDL-C levels, CETP activity, and lipoprotein size in this population, and these effects appear to translate into a lower CHD risk among those men with the B2 allele. Expand
The APOA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore Published, JLR Papers in Press, September 1, 2003. DOI 10.1194/jlr.M300251-JLR200
TLDR
Data suggest that APOA5 plays a role in the ethnic differences observed for plasma TG and HDL cholesterol concentrations for Chinese and Malays, and major associations between the minor alleles at each of four common polymorphisms and higher plasma triglycerides across ethnic groups. Expand
Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women.
TLDR
Low vitamin K intakes were associated with an increased incidence of hip fractures in this cohort of elderly men and women and neither low vitamin K intake nor E4 allele status was associated with low BMD. Expand
Serum Selenium Concentrations and Diabetes in U.S. Adults: National Health and Nutrition Examination Survey (NHANES) 2003–2004
TLDR
In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Expand
The PhenX Toolkit: Get the Most From Your Measures
TLDR
The PhenX Toolkit provides the research community with a core set of high-quality, well-established, low-burden measures intended for use in large-scale genomic studies and includes links to standards and resources in an effort to facilitate data harmonization to legacy data. Expand
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations
TLDR
These findings point to a molecular mechanism in humans by which higher triglycerides and CRP can be coupled with lower plasma glucose concentrations and position GCKR in central pathways regulating both hepatic triglyceride and glucose metabolism. Expand
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