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Role of the Fur Regulon in Iron Transport in Bacillus subtilis
TLDR
It is demonstrated that ywbLMN, encoding an elemental iron uptake system orthologous to the copper oxidase-dependent Fe(III) uptake system of Saccharomyces cerevisiae, is essential for growth in low iron minimal medium lacking citric acid. Expand
Listeria monocytogenes σB Modulates PrfA-Mediated Virulence Factor Expression
TLDR
Genome-wide transcript profiling and qRT-PCR showed that in the presence of active PrfA (PrfA*), σB is responsible for reduced expression of the Prf a regulon, highlighting the functional importance of regulatory interactions between Prf A and ρB. Expand
Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target
TLDR
It is demonstrated that clpP1 is essential for viability in this organism in culture, since the gene could only be deleted from the chromosome when a second functional copy was provided, and the genetic and chemical validation of ClpP as a drug target leads to new avenues for drug discovery. Expand
Transcriptomic and Phenotypic Analyses Identify Coregulated, Overlapping Regulons among PrfA, CtsR, HrcA, and the Alternative Sigma Factors σB, σC, σH, and σL in Listeria monocytogenes
TLDR
Identification of overlaps among the regulons provides strong evidence supporting the existence of complex regulatory networks that appear to provide the cell with regulatory redundancies, along with the ability to fine-tune gene expression in response to rapidly changing environmental conditions. Expand
Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis
TLDR
Results indicate that readily synthesized imidazo[1,2-a]pyridine-3-carboxamides are an exciting new class of potent, selective anti-TB agents that merit additional development opportunities. Expand
Inhibition of the Sole Type I Signal Peptidase of Mycobacterium tuberculosis Is Bactericidal under Replicating and Nonreplicating Conditions
TLDR
Proteins secreted by bacteria perform functions vital for cell survival and play a role in virulence in Mycobacterium tuberculosis, and LepB is a promising novel target for drug discovery in M. tuberculosis, since its inhibition results in rapid killing of persistent and replicating organisms. Expand
Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets.
TLDR
The authors summarize the current status of proteases with potential as drug targets in this pathogen, particularly focusing on proteases involved in protein secretion, protein degradation and turnover, and virulence. Expand
Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents
TLDR
Efforts toward the rational design of isomeric anagrams of a well-known sleep aid underscore the possibility that further optimization of the imidazo[1,2-a]pyridine core may well “put TB to rest”. Expand
Synthesis and evaluation of the 2,4-diaminoquinazoline series as anti-tubercular agents.
TLDR
An extensive evaluation of the 2,4-diaminoquinazoline series for its potential as a lead candidate for tuberculosis drug discovery found that the benzylic amine at the 4-position, the piperidine at 2-position and the N-1 (but not N-3) are key activity determinants. Expand
SigmaB- and PrfA-dependent transcription of genes previously classified as putative constituents of the Listeria monocytogenes PrfA regulon.
TLDR
The results suggest that the regulatory interactions between PrfA and sigma(B) contribute toPrfA's predominant role as a direct regulator of virulence genes critical for invasion and intracellular survival in L. monocytogenes 10403S, while sigma (B) regulates a wider range of virulent genes and stress response genes. Expand
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