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Distribution and release of epidermal growth factor in man.
TLDR
It is concluded that in man the major sources of EGF are salivary glands, duodenum, and pancreas and that the release of E GF remains under neurohormonal control. Expand
Comparison of intraduodenal and intravenous administration of amino acids on gastric secretion in healthy subjects and patients with duodenal ulcer.
TLDR
It is indicated that amino acids are capable of stimulating gastric secretion after intraduodenal and after intravenous administration and is strongly suppressed by histamine H2-blocker. Expand
Effect of atropine on gastrin and gastric acid response to peptone meal.
TLDR
It is concluded that atropine is a very strong inhibitor of meal-induced gastric acid secretion and does not significantly change serum gastrin response to feeding in duodenal ulcer patients when postprandial gastric Acidity and intragastric pressure are kept constant. Expand
Prostaglandins in peptic ulcer disease: effect of nonsteroidal anti-inflammatory compounds (NOSAC).
TLDR
It is indicated that the deficiency of endogenous PGs may play a role in the pathogenesis ulcer and that the degree of gastric mucosal damage by NOSAC is closely related to the alteration in the capability of the mucosa to generate PGs. Expand
Effect of atropine on gastric acid response to graded doses of pentagastrin and histamine in duodenal ulcer patients before and after vagotomy
TLDR
Significant inhibition of acid output was observed in basal secretion and at lower dose levels of gastric stimulation, whereas the maximal acid output remained unchanged both in patients with intact vagi and after surgical vagotomy. Expand
Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol.
TLDR
It is indicated that the gastric and duodenal mucosa is capable of generating PGE2-like activity which may be involved in the mechanism that protects the mucosa against the damage caused by aspirin. Expand
Comparison of methylated prostaglandin E2 analogues given orally in the inhibition of gastric responses to pentagastrin and peptone meal in man.
TLDR
These methylated PG analogues are very potent inhibitors of gastric acid and pepsin secretion stimulated by pentagastrin or a meal and may have clinical potential in the treatment of peptic ulcer. Expand
Double blind controlled study on the effect of sucralfate on gastric prostaglandin formation and microbleeding in normal and aspirin treated man.
TLDR
It is concluded that sucralfate has a potent protective action on spontaneous and aspirin treated gastric microbleeding in man and that this protection may be partly because of the increased mucosal biosynthesis of prostaglandins. Expand
Comparison of prostaglandin E2 and ranitidine in prevention of gastric bleeding by aspirin in man.
TLDR
It is confirmed that oral PGE2 has a protective action on gastric mucosa exposed to aspirin and that this property is also shared by ranitidine, a potent histamine H2-receptor antagonist. Expand
Prostaglandins and vagal stimulation of gastric secretion in duodenal ulcer patients.
TLDR
Exogenous PGE2 analog given orally significantly reduced gastric acid and pepsin secretion and suppressed serum PP but not gastrin responses to MSF, and merits clinical evaluation in the treatment of duodenal ulcer. Expand
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