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- Publications
- Influence
Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications.
- P. Marsham, L. R. Hughes, +6 authors A. Calvert
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 May 1991
The synthesis is described of a series of C2-methyl-N10-alkylquinazoline-based antifolates in which the p-aminobenzoate ring is replaced by the heterocycles thiophene, thiazole, thiadiazole,… Expand
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
- L. R. Hughes, A. Jackman, +7 authors A. Calvert
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 November 1990
Modification of the potent thymidylate synthase (TS) inhibitor N-[4-[N-[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-N-prop-2- ynylamino]benzoyl]-L-glutamic acid (1a) has led to the synthesis of… Expand
‘Chords of freedom’: Commemoration, ritual and British transatlantic slavery
- J. Oldfield
- History
- 2007
CONTENTS List of illustrations Acknowledgements Introduction One Frames of Remembrance: Benjamin Robert Haydon and The Anti-Slavery Convention, 1840 Two Literary Memorials: Clarkson's History and The… Expand
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Apparent role of melatonin and prolactin in initiating winter fur growth in mink.
- J. Rose, J. Oldfield, F. Stormshak
- Biology, Medicine
- General and comparative endocrinology
- 1 February 1987
A study was conducted to determine the effects of exogenous melatonin and bromocriptine (CB-154), an inhibitor of prolactin synthesis and secretion, on the induction of winter fur growth in mink.… Expand
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis.
- J. Cumming, H. Tucker, +7 authors J. Shaw
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 February 2012
Modifications to a series of potent and selective substituted 1-(3,3-diphenylpropyl)-piperidine phenylacetamide CCR5 antagonists were explored with the aim of reducing affinity at the hERG cardiac… Expand
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides.
- J. Cumming, A. Cooper, +7 authors D. Whittaker
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 November 2005
SAR and DMPK studies led to the identification of substituted N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides as potent and orally bioavailable ligands for the human CCR5… Expand
Quinazoline antifolate thymidylate synthase inhibitors: benzoyl ring modifications in the C2-methyl series.
- P. Marsham, A. Jackman, +6 authors A. Calvert
- Chemistry, Medicine
- Journal of medicinal chemistry
- 1 November 1990
The synthesis of nine new 2-methyl-10-propargylquinazoline antifolates with substituents in the p-aminobenzoyl ring is described. In general the synthetic route involved the coupling of the… Expand
Modulators of the human CCR5 receptor. Part 3: SAR of substituted 1-[3-(4-methanesulfonylphenyl)-3-phenylpropyl]-piperidinyl phenylacetamides.
- J. Cumming, S. J. Brown, +8 authors D. Whittaker
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 July 2006
SAR and PK studies led to the identification of N-(1-{(3R)-3-(3,5-difluorophenyl)-3-[4-methanesulfonylphenyl] propyl}piperidin-4-yl)-N-ethyl-2-[4-methanesulfonylphenyl]acetamide as a highly potent… Expand
VLSI and rule-based systems
- P. Kogge, J. Oldfield, M. Brule, C. Stormon
- Computer Science
- CARN
- 1 December 1988
TLDR
A High-Level Recognizer for Schematic Diagrams
- D. Tudhope, J. Oldfield
- Computer Science
- IEEE Computer Graphics and Applications
- 1 March 1983
TLDR