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Evaluation of oriental medicinal herbs for estrogenic and antiproliferative activities
Eriobotrya japonica showed strong cytotoxicity in ER‐negative breast cancer, cervix epitheloid (HeLa) and lung (A549) carcinoma cell lines, and in the antiproliferative assay, five human cancer cell lines representing different tissues were used. Expand
Marmesin-mediated suppression of VEGF/VEGFR and integrin β1 expression: Its implication in non-small cell lung cancer cell responses and tumor angiogenesis.
The pharmacological roles and molecular targets of marmesin in regulating NSCLC cell responses and tumor angiogenesis are demonstrated and demonstrate the role of inhibition of capillary-like structure formation in human umbilical vein endothelial cells. Expand
Lupenone Isolated from Adenophora triphylla var. japonica Extract Inhibits Adipogenic Differentiation through the Downregulation of PPARγ in 3T3‐L1 Cells
It is demonstrated that lupenone resulted in a significant reduction in lipid accumulation and expression of adipogenic marker genes in a dose‐dependent manner and effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene. Expand
1β-Hydroxy-2-oxopomolic acid isolated from Agrimonia pilosa extract inhibits adipogenesis in 3T3-L1 cells.
The data suggest that HOA isolated from Agrimonia pilosa inhibits adipocyte differentiation through downregulation of various adipocytokines by blocking PPARγ and C/EBPα expression. Expand
5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways.
The findings demonstrate the pharmacological roles and molecular targets of 5-CQA in regulating NSCLC cell fate, and suggest further evaluation and development of 4-caffeoylquinic acid as a potential therapeutic agent for the treatment and prevention of lung cancer. Expand
Anti-melanogenic and anti-oxidant activities of ethanol extract of Kummerowia striata: Kummerowia striata regulate anti-melanogenic activity through down-regulation of TRP-1, TRP-2 and MITF expression
Highlights • Ethanol extract of Kummerowia striata is a potent antioxidant.• It inhibits melanin synthesis by downregulating tyrosinase and related proteins.• It may be used in cosmetics for skinExpand
N‑trans‑ρ‑caffeoyl tyramine isolated from Tribulus terrestris exerts anti‑inflammatory effects in lipopolysaccharide‑stimulated RAW 264.7 cells.
Findings indicate that CT isolated from T. terrestris is a novel and potent modulator of inflammatory responses, and it may prove benefiical to further evaluate CT as a possible treatment for chronic inflammatory diseases. Expand
Excavasides A and B, two new flavonoid glycosides from Clausena excavata Burm. f. (Rutaceae)
Abstract Two new flavonoid glycosides, excavaside A ( 1 ) and B ( 2 ), together with 14 known compounds, myricetin 3- O -β- d -rutinoside ( 3 ), myricetin 3,3′-di-α- l -rhamnopyranoside ( 4 ),Expand
A mechanistic study on the anti-cancer activity of ethyl caffeate in human ovarian cancer SKOV-3 cells.
EC-mediated inhibition of cell proliferation in SKOV-3 cells was accompanied by reduced expression of cell cycle-related proteins such as cyclin-dependent kinases and cyclins, resulting in pRb hypophosphorylation and G₁ phase cell cycle arrest, and EC treatment markedly inhibited cell migration and invasion. Expand
Marmesin is a novel angiogenesis inhibitor: Regulatory effect and molecular mechanism on endothelial cell fate and angiogenesis.
The findings clearly support the pharmacological roles of marmesin in regulating angiogenesis, and warrant further evaluation and development as a potential therapeutic agent for the treatment and prevention of angiogenic-related diseases including cancer. Expand