J. Oakeshott

Publications248
h-index57
Citations12,687
Highly Influential Citations595
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A deficit of detoxification enzymes: pesticide sensitivity and environmental response in the honeybee
TLDR
There are some recent radiations in CYP6, CYP9 and certain CCE clades in A. mellifera that could be associated with the evolution of the hormonal and chemosensory processes underpinning its highly organized eusociality.
Biochemical Genetics and Genomics of Insect Esterases
Functional and Evolutionary Insights from the Genomes of Three Parasitoid Nasonia Species
TLDR
Key findings include the identification of a functional DNA methylation tool kit; hymenopteran-specific genes including diverse venoms; lateral gene transfers among Pox viruses, Wolbachia, and Nasonia; and the rapid evolution of genes involved in nuclear-mitochondrial interactions that are implicated in speciation.
Enrichment of an Endosulfan-Degrading Mixed Bacterial Culture
TLDR
The results suggest that this mixed culture is worth investigating as a source of endosulfan-hydrolyzing enzymes for use in enzymatic bioremediation of endOSulfan residues.
Insights into social insects from the genome of the honeybee Apis mellifera
TLDR
The genome sequence of the honeybee Apis mellifera is reported, suggesting a novel African origin for the species A. melliferA and insights into whether Africanized bees spread throughout the New World via hybridization or displacement.
A single amino acid substitution converts a carboxylesterase to an organophosphorus hydrolase and confers insecticide resistance on a blowfly.
TLDR
In vitro expression of two natural and two synthetic chimeric alleles shows that the Asp137 substitution alone is responsible for both the loss of E3's carboxylesterase activity and the acquisition of a novel OP hydrolase activity.
Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation
TLDR
It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation.
Two different amino acid substitutions in the ali-esterase, E3, confer alternative types of organophosphorus insecticide resistance in the sheep blowfly, Lucilia cuprina
Identification of an opd (Organophosphate Degradation) Gene in an Agrobacterium Isolate
TLDR
It is suggested that Insertional mutation of the opdA gene produced a strain lacking the ability to hydrolyze OPs, suggesting that this is the only gene encoding an OP-hydrolyzing enzyme in A. radiobacter P230.
The genomes of two key bumblebee species with primitive eusocial organization
TLDR
Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation.
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