Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2.
The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis.
Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.
- E. Griffith, Z. Su, J. O. Liu
- Biology, ChemistryChemistry and Biology
- 1 June 1997
Selective inhibition of amino-terminal methionine processing by TNP-470 and ovalicin in endothelial cells.
- B. Turk, E. Griffith, S. Wolf, K. Biemann, Y. Chang, J. O. Liu
- BiologyChemistry and Biology
- 1 November 1999
A three-hybrid system for detecting small ligand-protein receptor interactions.
- E. Licitra, J. O. Liu
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 12 November 1996
It is demonstrated that the three-hybrid system can be used to discover receptors for small ligands and to screen for new ligands to known receptors.
Overexpression and purification of human calcineurin alpha from Escherichia coli and assessment of catalytic functions of residues surrounding the binuclear metal center.
- A. Mondragon, E. Griffith, L. Sun, F. Xiong, C. Armstrong, J. O. Liu
- Biology, ChemistryBiochemistry
- 22 April 1997
An efficient bacterial expression and purification system for human calcineurin alpha is reported and it was found that an intact binuclear metal center is essential for the catalytic activity of the enzyme.
Calcium Regulates Transcriptional Repression of Myocyte Enhancer Factor 2 by Histone Deacetylase 4*
- H. Youn, C. Grozinger, J. O. Liu
- BiologyJournal of Biological Chemistry
- 21 July 2000
Together, HDAC4, MITR, and Cabin1 constitute a family of calcium-sensitive transcriptional repressors of MEF2, which contains calmodulin-binding domains that overlap with their MEF 2- binding domains.
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2.
- E. Griffith, Z. Su, S. Niwayama, C. Ramsay, Y. Chang, J. O. Liu
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 22 December 1998
The results, in agreement with a recent structural study, suggest that fumagillin and ovalicin inhibit MetAP2 by irreversible blockage of the active site.
p53-independent apoptosis induced by paclitaxel through an indirect mechanism.
- J. Lanni, S. Lowe, E. Licitra, J. O. Liu, T. Jacks
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 2 September 1997
The results suggest that the efficacy of paclitaxel in vivo may be due not only to its microtubule-stabilizing activity, but its ability to activate local release of an apoptosis-inducing cytokine.
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