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Androgens and androgen receptor signaling in prostate tumorigenesis.
Androgens and androgen receptor (AR) signaling are necessary for prostate development and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The role of androgens… Expand
Inhibition of the NF-κB Pathway by Varicella-Zoster Virus In Vitro and in Human Epidermal Cells In Vivo
ABSTRACT Varicella-zoster virus (VZV) is an alphaherpesvirus that causes varicella and herpes zoster. Using human cellular DNA microarrays, we found that many nuclear factor kappa B… Expand
Non-competitive androgen receptor inhibition in vitro and in vivo
- J. O. Jones, Eric C Bolton, +5 authors M. Diamond
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 28 April 2009
Androgen receptor (AR) inhibitors are used to treat multiple human diseases, including hirsutism, benign prostatic hypertrophy, and prostate cancer, but all available anti-androgens target only… Expand
Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract.
Novel estrogenic therapies are needed that ameliorate menopausal symptoms and have the bone-sparing effects of endogenous estrogens but do not promote breast or uterine cancer. Recent evidence… Expand
Effects of parabens on adipocyte differentiation.
- Pan Hu, X. Chen, +5 authors L. Zhao
- Chemistry, Medicine
- Toxicological sciences : an official journal of…
Parabens are a group of alkyl esters of p-hydroxybenzoic acid that include methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. Paraben esters and their salts are widely used… Expand
Microarray Analysis of Host Cell Gene Transcription in Response to Varicella-Zoster Virus Infection of Human T Cells and Fibroblasts In Vitro and SCIDhu Skin Xenografts In Vivo
ABSTRACT During primary infection, varicella-zoster virus (VZV) is spread via lymphocytes to skin, where it induces a rash and establishes latency in sensory ganglia. A live, attenuated varicella… Expand
Detection and phenotyping of circulating tumor cells in high-risk localized prostate cancer.
BACKGROUND In this study, we aimed to determine the feasibility of identifying CTCs in patients with HRLPC, using a modified isolation procedure using the CellSearch (Veridex) platform, and to assess… Expand
Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium.
- Minyoung Lim, M. Otto-Duessel, +5 authors J. O. Jones
- Chemistry, Medicine
- ACS chemical biology
- 21 March 2014
Pyrvinium pamoate (PP) is a potent noncompetitive inhibitor of the androgen receptor (AR). Using a novel method of target identification, we demonstrate that AR is a direct target of PP in prostate… Expand
Clinical outcome in patients receiving systemic therapy for metastatic sarcomatoid renal cell carcinoma: a retrospective analysis.
OBJECTIVES Sarcomatoid metastatic renal cell carcinoma (mRCC) represents an aggressive subset of disease, and a definitive therapeutic strategy is lacking. We seek to define outcomes associated with… Expand
Rationalizing the development of live attenuated virus vaccines
The design of vaccines against viral disease has evolved considerably over the past 50 years. Live attenuated viruses (LAVs)—those created by passaging a virus in cultured cells—have proven to be an… Expand