• Publications
  • Influence
Lysobactin, a novel antibacterial agent produced by Lysobacter sp. I. Taxonomy, isolation and partial characterization.
A new antibacterial agent, lysobactin, has been isolated from a species of Lysobacter (ATCC 53042) by extraction and reversed phase chromatography. Expand
Lanomycin and glucolanomycin, antifungal agents produced by Pycnidiophora dispersa. I. Discovery, isolation and biological activity.
These compounds inhibited the cytochrome P-450 enzyme lanosterol 14 alpha-demethylase, and are believed, therefore, to have a mode of action similar to the azole and bis-triazole class of antifungal agents. Expand
Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase.
The effectiveness of the quinolones indicates that bacterial DNA gyrase is a target for clinically useful antibacterial agents, which has stimulated interest in searches for non-quinolone DNAGyrase inhibitors. Expand
Naturally occurring monobactams.
The monobactam nucleus and analogs with a variety of substituents in the 1, 3, and 4-positions of the azetidinone ring are readily accessible by synthesis and are probable that further clinically useful antimicrobial agents will follow. Expand
Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.
Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum that are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Expand
Biosynthesis of monobactam compounds: origin of the carbon atoms in the beta-lactam ring
In the three organisms, the carbon atoms of the beta-lactam ring of the monobactam are derived directly from serine without the loss of the C-3 hydrogen atoms, probably by an SN2 ring closure mechanism. Expand
Ascosteroside, a new antifungal agent from Ascotricha amphitricha. I. Taxonomy, fermentation and biological activities.
Ascosteroside, a novel antifungal compound, was isolated from the culture broth of Ascotricha amphitricha and afforded protection comparable to that of ketoconazole in a mouse model. Expand
Dactylocyclines: novel tetracycline glycosides active against tetracycline-resistant bacteria
The dactylocycline antibiotics are a series of tetracycline glycosides with absolute stereochemistry at C-6 (R) unprecedented amongst natural tetracyclines which, in addition, display an unusualExpand
Sulfur metabolism in the biosynthesis of monobactams
We studied the biosynthesis of monobactams with respect to sulfur metabolism in Chromobacterium violaceum, Acetobacter sp., and Agrobacterium radiobacter. All three organisms used inorganic sulfurExpand