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Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats.
TLDR
It is suggested that estradiol may play a role in enhancement of Leydig cell tumors in the rat, and that peroxisome proliferators may induce tumors via a non-LH type mechanism.
The Toxicology of Perfluorooctanoate
TLDR
The hepatocellular tumors observed in rats are likely to have been the result of the activation of the peroxisome proliferator activated receptor α (PPARα), and the proposed mechanism for Leydig-cell tumor formation is of questionable relevance to humans.
Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens.
TLDR
5 of the six test substances were identified as endocrine-active substances consistent with their known/proposed mechanism(s) of action and increased relative liver weight, illustrating that the ability to identify EACs using the intact male assay will be equivalent regardless of the route of compound administration.
90-day feeding and one-generation reproduction study in Crl:CD BR rats with 17 beta-estradiol.
TLDR
This 90-day/one-generation reproduction study with 17 beta-estradiol was designed to set dose levels for future multigenerational reproduction and combined chronic toxicity/oncogenicity studies, and to provide benchmark data for a risk assessment for chemicals with estrogen-like activities.
Detection of thyroid toxicants in a tier I screening battery and alterations in thyroid endpoints over 28 days of exposure.
TLDR
The dietary restriction study demonstrated that possible confounding of the data can occur with the thyroid endpoints when body weight decrements are 15% or greater, and suggested that 2 weeks is the optimal time point for identifying thyroid toxicants based on the 9 endpoints examined.
Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators.
TLDR
This article illustrates that the ability to identify EACs using the intact male assay will be equivalent regardless of the route of compound administration, and supports this assay as a viable screening assay for detecting endocrine-active compounds.
Effects of dietary 17 beta-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BR rats.
TLDR
The data demonstrate that in utero and postnatal dietary administration of 17 beta-estradiol at levels which increased serum estradiol levels to approximately 400% of control and decreased testosterone levels to 33% ofControl did not reduce the number of Sertoli cell nuclei per testis.
Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay.
TLDR
It is suggested that strain selection will affect the ability to detect certain weak EACs, and a Tier I screening battery consisting of both in vivo and in vitro endpoints would reduce the chance that weak-acting compounds such as p,p'-DDE would not be identified as potential Eacs.
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