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The spectrum of inherited mutations causing HPRT deficiency: 75 new cases and a review of 196 previously reported cases.
Genotoxic markers among butadiene polymer workers in China.
Overall, the study demonstrated exposure to butadiene in these workers, by a variety of short-term and long-term measures, but did not show specific genotoxic effects, at the chromosomal or gene levels, related to that exposure.
hprt mutation frequency among workers exposed to 1,3-butadiene in China.
High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination.
The results indicate that mitotic recombination and, to a much lesser extent, deletion may be the primary mechanisms for the relatively high frequency of in vivo LOH observed in normal human T cells.
In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns.
- F. Perera, K. Hemminki, J. O’Neill
- Medicine, BiologyCancer epidemiology, biomarkers & prevention : a…
- 1 October 2002
It is shown that aromatic-DNA adducts measured by (32)P-postlabeling are positively associated with HPRT mutant frequency in the newborns, the first demonstration of a molecular link between somatic mutation in the babies and transplacental exposure to common air pollutants.
Increased frequency of specific genomic deletions resulting from in vitro malathion exposure.
This work provides the first evidence of an association between malathion exposure and specific mutations in human T lymphocytes, and the underlying molecular mechanism for these deletions is necessary to determine.
Evaluation of Salmonella enterica serovar Typhi (Ty2 aroC-ssaV-) M01ZH09, with a defined mutation in the Salmonella pathogenicity island 2, as a live, oral typhoid vaccine in human volunteers.
Markers for carcinogenicity among butadiene-polymer workers in China.
In vivo somatic mutations in humans: measurement and analysis.
Genes Scored in Red Cells, T-lymphoc ytes, and T-Lymphocytes are revealed.
Determination of hprt mutant frequencies in T-lymphocytes from a healthy pediatric population: statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and…