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Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer
We conducted a genome-wide association study for testicular germ cell tumor, genotyping 298,782 SNPs in 979 affected individuals and 4,947 controls from the UK and replicating associations in aExpand
A genome-wide association study of testicular germ cell tumor
KITLG, encoding the ligand for the receptor tyrosine kinase KIT, which has previously been implicated in the pathogenesis of TGCT and the biology of germ cells, may explain the association on chromosome 12. Expand
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
Nine new loci are identified showing association with TGCT, which together account for an additional 4–6% of the familial risk of TGCT. Expand
Linkage Disequilibrium in the Domesticated Pig
The results suggest that mapping methods based on LD may be valuable even with only moderately dense marker spacing in pigs, and that the distance explained most of the variability of D′. Expand
Gene Expression Profiling of Paraffin-Embedded Primary Melanoma Using the DASL Assay Identifies Increased Osteopontin Expression as Predictive of Reduced Relapse-Free Survival
Purpose: Gene expression studies in melanoma have been few because tumors are small and cryopreservation is rarely possible. The purpose of this study was to evaluate the Illumina DASL Array HumanExpand
Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor
A new GWAS is reported, a meta-analysis with previous GWAS and a replication series are reported, indicating widespread disruption of developmental transcriptional regulators as a basis of TGCT susceptibility, consistent with failed primordial germ cell differentiation as an initiating step in oncogenesis. Expand
Patterns of Expression of DNA Repair Genes and Relapse From Melanoma
Overexpression of DNA repair genes (predominantly those involved in double-strand break repair) was associated with relapse and supported the hypothesis that melanoma progression requires maintenance of genetic stability and give insight into mechanisms of melanoma drug resistance and potential therapies. Expand
β-Catenin–mediated immune evasion pathway frequently operates in primary cutaneous melanomas
Evidence for a &bgr;-catenin–mediated immune evasion in 42% of melanoma primaries overall and in 73% of those with the worst outcome is reported, suggesting that patient stratification will improve immunotherapeutic outcomes. Expand
Multi-stage genome-wide association study identifies new susceptibility locus for testicular germ cell tumour on chromosome 3q25.
Through fixed-effects meta-analysis across three stages, a novel locus at 3q25.31 demonstrating association with TGCT is identified, and new genotyping of eight SNPs showing some evidence of association is reported. Expand
Consensus of Melanoma Gene Expression Subtypes Converges on Biological Entities.
Three melanoma gene expression subtypes were reported in 2015: the immune group was characterized by increased expression of immune genes; the high-immune, normal-like, microphthalmia-associated transcription factor (MITF)-high pigmentation, and MITF-low proliferative groups. Expand