Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
- I. Lastres-Becker, S. Brodesser, +7 authors G. Auburger
- Biology, Medicine
- Human molecular genetics
- 15 May 2008
Ataxin-2 is a cytoplasmic protein, product of the SCA2 gene. Expansion of the normal polyglutamine tract in the protein leads to the neurodegenerative disorder Spino-Cerebellar Ataxia type 2 (SCA2).… Expand
Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
- David Nonis, Mirko H.H. Schmidt, +4 authors G. Auburger
- Biology, Medicine
- Cellular signalling
- 1 October 2008
Ataxin-2 is a novel protein, where the unstable expansion of an internal polyglutamine domain can cause the neurodegenerative disease Spinocerebellar Ataxia type 2 (SCA2). To elucidate its cellular… Expand
ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice
- E. Damrath, Melanie Heck, +6 authors G. Auburger
- Medicine, Biology
- PLoS genetics
- 1 August 2012
Spinocerebellar Ataxia Type 2 (SCA2) is caused by expansion of a polyglutamine encoding triplet repeat in the human ATXN2 gene beyond (CAG)31. This is thought to mediate toxic gain-of-function by… Expand
The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer.
- J. Nowock, U. Borgmeyer, A. Püschel, R. A. Rupp, A. Sippel
- Biology, Medicine
- Nucleic acids research
- 25 March 1985
TGGCA-binding proteins are nuclear proteins with high affinity for double-stranded DNA homologous to the prototype recognition sequence 5'YTGGCANNNTGCCAR 3'. Their ubiquitous tissue distribution in… Expand
Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme gene
- H. Fritton, T. Igo-Kemenes, J. Nowock, U. Strech-Jurk, M. Theisen, A. Sippel
- Biology, Medicine
- Nature
- 13 September 1984
The structural organization of chromatin is thought to determine the state of differentiation and activity of eukaryotic genes. Local interruptions of the regular nucleosomal array, the so-called… Expand
A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells.
- M. Grez, M. Zörnig, J. Nowock, M. Ziegler
- Biology, Medicine
- Journal of virology
- 1 September 1991
The expression of Moloney murine leukemia virus (Mo-MuLV) and Mo-MuLV-derived vectors is restricted in undifferentiated mouse embryonal carcinoma and embryonal stem (ES) cells. We have previously… Expand
Ataxin-2 promotes apoptosis of human neuroblastoma cells
- R. Wiedemeyer, F. Westermann, I. Wittke, J. Nowock, M. Schwab
- Biology, Medicine
- Oncogene
- 23 January 2003
Neuroblastoma is a highly heterogeneous tumor of young children. Although many advances have been made towards understanding the molecular mechanisms dictating the phenotypic heterogeneity, the… Expand
The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA.
- U. Borgmeyer, J. Nowock, A. Sippel
- Biology, Medicine
- Nucleic acids research
- 25 May 1984
Low salt extracts of chicken oviduct nuclei contain a DNA binding protein with high affinity for specific DNA sequences in the flanking regions of the chicken lysozyme gene. Two of the three binding… Expand
Interaction of the TGGCA‐binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus.
- R. Miksicek, U. Borgmeyer, J. Nowock
- Biology, Medicine
- The EMBO journal
- 1 May 1987
A high‐affinity binding site for the TGGCA‐binding protein, also known as nuclear factor I, has previously been shown to reside within the mouse mammary tumor virus (MMTV) long terminal repeat. We… Expand
Cooperation of GATA-1 and Sp1 can result in synergistic transcriptional activation or interference.
- K. D. Fischer, A. Haese, J. Nowock
- Biology, Medicine
- The Journal of biological chemistry
- 15 November 1993
GATA-1 is a lineage-restricted transcription factor. Virtually all erythroid-expressed genes contain GATA recognition sites in their regulatory elements. Cotransfection/transactivation assays have… Expand