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Insulin receptor and lipid metabolism pathology in ataxin-2 knock-out mice.
TLDR
The data suggest altered signaling in ataxin-2 deficient organisms and increased levels of gangliosides and sulfatides, as well as decreased cholesterol dynamics, may be relevant for cellular membrane functions, and alterations in the sphingomyelin cycle may affect second messengers.
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The TGGCA protein binds to the MMTV-LTR, the adenovirus origin of replication, and the BK virus enhancer.
TLDR
The TGGCA-binding protein from HeLa cells appears to be identical to nuclear factor I described by others, which stimulates initiation of adenovirus DNA replication in vitro, which suggests that this specific protein-DNA interaction may also be involved in the control of gene activity.
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A single point mutation activates the Moloney murine leukemia virus long terminal repeat in embryonal stem cells
TLDR
It is shown that replacement of the Mo-MuLV enhancer region by sequences derived from the MESV LTR results in the activation of theMo-Mu LV LTR in ES cells and to confer enhancer-dependent expression to Mo- MuLV-derived retroviral vectors inES cells.
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Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking.
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Functional homology between the sequence‐specific DNA‐binding proteins nuclear factor I from HeLa cells and the TGGCA protein from chicken liver.
TLDR
Using deletion and substitution mutants derived from the DNA binding site on the adenovirus 2 inverted terminal repeat, it was found that the two proteins protect the same 24‐nucleotide region of both strands against DNase I digestion and that they have identical minimal recognition sequences of 15 bp containing dyad symmetry.
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Ataxin-2 promotes apoptosis of human neuroblastoma cells
TLDR
It is suggested that ataxin-2 has an important role in regulating the susceptibility of neuroblastoma cells to apoptotic stimuli in vitro and in vivo.
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ATXN2-CAG42 Sequesters PABPC1 into Insolubility and Induces FBXW8 in Cerebellum of Old Ataxic Knock-In Mice
TLDR
The data support the concept that expanded ATXN2 undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8.
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The TGGCA-binding protein: a eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA.
TLDR
Low salt extracts of chicken oviduct nuclei contain a DNA binding protein with high affinity for specific DNA sequences in the flanking regions of the chicken lysozyme gene that can be detected in nuclei from several chicken tissues and from mouse liver.
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Interaction of the TGGCA‐binding protein with upstream sequences is required for efficient transcription of mouse mammary tumor virus.
A high‐affinity binding site for the TGGCA‐binding protein, also known as nuclear factor I, has previously been shown to reside within the mouse mammary tumor virus (MMTV) long terminal repeat. We…
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Alternative sets of DNase I-hypersensitive sites characterize the various functional states of the chicken lysozyme gene
TLDR
Two new observations on the chromatin structure of the chicken lysozyme gene are presented, which strongly support a regulatory function for DNase I-hypersensitive sites and reflect the transition from the potentially active to the active state of the lyso enzyme gene.
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