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Identification of domains in canine parvovirus VP2 essential for the assembly of virus-like particles.
Canine parvovirus capsids are composed of 60 copies of VP2 and 6 to 10 copies of VPl. To locate essential sites of interaction between VP2 monomers, we have analyzed the effects of a number of VP2Expand
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Selective inhibition of in vitro cell growth by the anti-tumour drug Ukrain.
The inhibitory effect of Ukrain on malignant cells and on normal cells, in vitro, has been compared. To obtain a 50% inhibition of cell growth, a tenfold concentration had to be used with normalExpand
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Induction of bimodal programmed cell death in malignant cells by the derivative Ukrain (NSC-631570).
Selective induction of malignant cell death is one of the major goals of effective and safe chemotherapy. Recent developments in the understanding of programmed cell death (PCD) or apoptosis areExpand
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Ukrain: a novel antitumor drug.
A review of the recent literature on the new anticancer drug Ukrain is provided herein. We review Ukrain, a thiophosphate derivative of alkaloids from Chelidonium majus L., its capacity to exertExpand
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Estimation of direct influence of Ukrain preparation on influenza viruses and the bacteria E. coli and S. aureus.
Ukrain is a semisynthetic drug with immunomodulatory properties derived from Chelidonium majus L. alkaloids and thiophosphoric acid. It acts selectively in a lytic way on cancer cells. Its protectiveExpand
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Modulation of immune effector cell cytolytic activity and tumour growth inhibition in vivo by Ukrain (NSC 631570).
Ukrain is a semisynthetic compound consisting of alkaloids from Chelidonium majus L. conjugated to thiophosphoric acid, with immunomodulatory and therapeutic properties in cancer patients. TheExpand
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Influence of Ukrain on patients with surgically treated breast cancer. Part II. Hormonal profile.
The present study was undertaken to evaluate the influence of Ukrain on the hormonal status of ten patients with breast cancer, treated in the preoperative phase by Ukrain. A control group consistedExpand
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Evaluation of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. ("Ukrain") as an immunostimulant in patients with various carcinomas.
This paper summarizes the preliminary results of two independent clinical trials conducted with the preparation "Ukrain", containing thiophosphoric acid alkaloid derivatives from the plantExpand
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Effect of six-month treatment with Ukrain on early osteoporosis induced by ovariectomy in rats. Part III. Preliminary studies of some hormone levels.
The effect of six-month treatment with Ukrain on the level of some hormones was investigated in ovariectomized rats. The serum levels of prolactin, adrenocorticotropic hormone (ACTH), corticosterone,Expand
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Effect of single and prolonged administration of Ukrain on prolactin concentration in rats.
The effect of single and prolonged administration of Ukrain on the serum prolactin concentrations in rats of both sexes was investigated. One hour after intraperitoneal (i.p.) administration ofExpand
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