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The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability.
The outcome of multiple sclerosis (MS), assessed according to the Kurtzke Disability Status Scale (DSS), was reviewed in 1,099 consecutive patients followed in London, Canada, between 1972 and 1984.… Expand
Steroid-responsive encephalopathy associated with autoimmune thyroiditis.
BACKGROUND Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), often termed Hashimoto encephalopathy, is a poorly understood and often misdiagnosed entity. OBJECTIVE… Expand
Executive Leadership and Physician Well‐being: Nine Organizational Strategies to Promote Engagement and Reduce Burnout
Abstract These are challenging times for health care executives. The health care field is experiencing unprecedented changes that threaten the survival of many health care organizations. To… Expand
A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease
There are no established treatments for patients with acute, severe neurological deficits caused by multiple sclerosis or other inflammatory demyelinating diseases of the central nervous system who… Expand
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system (CNS). Diagnosis rests upon identifying typical clinical symptoms and interpreting supportive laboratory and… Expand
Progress in determining the causes and treatment of multiple sclerosis
- J. Noseworthy
- 24 June 1999
The cause of multiple sclerosis remains unknown after more than a century of study. Unconfirmed work has once more indicated that a viral infection may be important in the aetiology of the disease,… Expand
Incidence and prevalence of multiple sclerosis in Olmsted County, Minnesota, 1985–2000
- W. T. Mayr, S. Pittock, R. McClelland, N. Jorgensen, J. Noseworthy, M. Rodriguez
- 25 November 2003
Background: Epidemiologic data for multiple sclerosis (MS) in Olmsted County, MN, have been recorded for almost 100 years and have indicated that the increasing prevalence rate was likely due in part… Expand
Multiple Sclerosis: Current Pathophysiological Concepts
Multiple sclerosis (MS) is an often disabling disease primarily affecting young adults that exhibits extraordinary clinical, radiological, and pathological heterogeneity. We review the following: (a)… Expand
Disability as an outcome in MS clinical trials
Background: Inferences about long-term effects of therapies in multiple sclerosis (MS) have been based on surrogate markers studied in short-term trials. Preventing progressive disability is the key… Expand