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Integrins: masters and slaves of endocytic transport
New findings indicate that integrin trafficking dictates the nature of Rho GTPase signalling during cytokinesis and cell migration and can exert control over the trafficking of other receptors in a way that drives cancer cell invasion and tumour angiogenesis.
Mutant p53 Drives Invasion by Promoting Integrin Recycling
Integrin Trafficking and the Control of Cell Migration
The findings of studies revealing the molecular mechanisms controlling integrin traffic are summarized, particularly those providing indications as to how these processes contribute to cell migration and tumour cell invasiveness.
Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
- P. Caswell, May P. Chan, Andrew J. Lindsay, M. Mccaffrey, D. Boettiger, J. Norman
- BiologyThe Journal of cell biology
- 6 October 2008
It is concluded that RCP provides a scaffold that promotes the physical association and coordinate trafficking of α5β1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices.
p53 and its mutants in tumor cell migration and invasion
It is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion, and that mutant p53s can acquire new functions to drive cell migration, invasion and metastasis, in part by interfering with p63 function.
PDGF-regulated rab4-dependent recycling of αvβ3 integrin from early endosomes is necessary for cell adhesion and spreading
Structure and function of the complex formed by the tuberculosis virulence factors CFP‐10 and ESAT‐6
The surface features of the CFP‐10·ESAT‐6 complex strongly suggest a key signalling role for the complex, in which binding to cell surface receptors leads to modulation of host cell behaviour to the advantage of the pathogen.
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane.
Mechanisms of integrin activation and trafficking.
PDGF-regulated rab4-dependent recycling of alphavbeta3 integrin from early endosomes is necessary for cell adhesion and spreading.
It is proposed that growth factor-regulated, rab4-dependent recycling of alphavbeta3 integrin from early endosomes to the plasma membrane is a critical upstream event in the assembly of cell-matrix contacts.