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Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.
Aging in humans is accompanied by a progressive decline in the secretion of the adrenal androgens dehydroepiandrosterone (DHEA) and DHEA sulfate (DS), paralleling that of the GH-insulin-like growthExpand
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A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test. Diabetes Care 2001;24:539–548
OBJECTIVE Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulinExpand
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Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone.
BACKGROUND Troglitazone decreases insulin resistance and hyperglycemia in patients with non-insulin-dependent diabetes mellitus (NIDDM), but its effects on subjects without diabetes are not known. Expand
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A Model-Based Method for Assessing Insulin Sensitivity From the Oral Glucose Tolerance Test
OBJECTIVE —Available insulin sensitivity (IS) methods based on the oral glucose tolerance test (OGTT) are empirical. We used a glucose-insulin model to derive an OGTT-based IS (oral glucose insulinExpand
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Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus.
BACKGROUND Some animal studies have suggested that conjugated linoleic acid (CLA) supplementation may have therapeutic potential with respect to insulin sensitivity and lipid metabolism, which areExpand
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Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Ruth Loos and colleagues report findings from a meta-analysis of multiple studies examining the extent to which physical activity attenuates effects of a specific gene variant, FTO, on obesity inExpand
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Metabolic Effects of New Oral Hypoglycemic Agent CS-045 in NIDDM Subjects
Objective — To study the metabolic effects of a new oral antidiabetic agent, CS-045, in subjects with non-insulin-dependent diabetes mellitus (NIDDM). Research Design And Methods — Eleven NIDDMExpand
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Acute and Chronic Effect of Insulin on Leptin Production in Humans: Studies In Vivo and In Vitro
This study was undertaken to investigate the changes in obesity (OB) gene expression and production of leptin in response to insulin in vitro and in vivo under euglycemic and hyperglycemic conditionsExpand
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Exercise training increases insulin-stimulated glucose disposal and GLUT4 (SLC2A4) protein content in patients with type 2 diabetes
Aims/hypothesisExercise enhances insulin-stimulated glucose transport in skeletal muscle through changes in signal transduction and gene expression. The aim of this study was to assess the impact ofExpand
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Plasma visfatin is reduced after aerobic exercise in early onset type 2 diabetes mellitus
Visfatin is an adipokine [1] that has been shown to be significantly elevated in people with type 2 diabetes mellitus and independently associated with waist–hip ratio [2] and body mass index (BMI)Expand
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