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Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer
It is suggested that inhibition of S6K1 by RAME can induce autophagy and apoptosis in cervical cancer cells, and provide a potential option for cervical cancer treatment, particularly when combined with cisplatin. Expand
Design, syntheses and biological evaluations of nonpeptidic caspase 3 inhibitors
Caspase 3, a member of cysteine protease family, is well known as a major apoptosis effector and is involved in cell death as a result of ischemic diseases such as stroke and myocardial infarction,Expand
Theoretical Study on Hydrophobicity of Amino Acids by the Solvation Free Energy Density Model
In order to characterize the hydrophobic parameters of N-acetyl amino acid amides in 1-octanol/water, a theoretical calculation was carried out using a solvation free energy density model. TheExpand
Reactions of Thianthrene Cation radical Perchlorate with 1-Alkyl-4-Arenesulfonylaminobenzenes
Reaction of thianthrene cation radical perchlorate (1) with 1-methyl-4-benzenesulfonylaminobenzene (10) afforded thianthrene (5), N-(4-tolyl)-N-thianthrenylbenzenesulfonamide (14),Expand
Reaction of Thianthrene Cation Radical Perchlorate With N-Free and N-Alkylsulfonamides
Thianthrene cation radical perchlorate (1) reacted with N-free sulfonamides to give directly N-sulfonylsulfilimines (5a-5c) but reaction with N-alkylsulfonamides afforded, inter alia,Expand