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A model of posttraumatic epilepsy induced by lateral fluid-percussion brain injury in rats
Although traumatic brain injury is a major cause of symptomatic epilepsy, the mechanism by which it leads to recurrent seizures is unknown. An animal model of posttraumatic epilepsy that reliablyExpand
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A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat
Spontaneous seizures are the hallmark of human epilepsy but they do not occur in most of the epilepsy models that are used to investigate the mechanisms of epilepsy or to test new antiepilepticExpand
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Cyclicity of spontaneous recurrent seizures in pilocarpine model of temporal lobe epilepsy in rat
Pilocarpine administration to rats results in status epilepticus (SE) and after a latency period to the occurrence of spontaneous seizures. The model is commonly used to investigate mechanisms ofExpand
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Effect of novel AMPA antagonist, NS1209, on status epilepticus: An experimental study in rat
The current first line treatment of status epilepticus (SE) is based on the use of compounds that enhance GABAergic transmission or block sodium channels. These treatments discontinue SE in onlyExpand
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Epileptogenesis in Experimental Models
Summary:  Epileptogenesis refers to a phenomenon in which the brain undergoes molecular and cellular alterations after a brain‐damaging insult, which increase its excitability and eventually lead toExpand
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Decreased BDNF signalling in transgenic mice reduces epileptogenesis
Brain derived neurotrophic factor (BDNF) has been suggested to be involved in epileptogenesis. Both pro‐ and antiepileptogenic effects have been reported, but the exact physiological role is stillExpand
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Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy.
Temporal lobe epilepsy remains amongst the most common and drug refractory of neurological disorders. Gene therapy may provide a realistic therapeutic approach alternative to surgery for intractableExpand
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Progression of Brain Damage after Status Epilepticus and Its Association with Epileptogenesis: A Quantitative MRI Study in a Rat Model of Temporal Lobe Epilepsy
Summary:  Purpose: This study examined the hypothesis that neurodegeneration continues after status epilepticus (SE) ends and that the severity of damage at the early phase of the epileptogenicExpand
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Effect of lamotrigine treatment on status epilepticus-induced neuronal damage and memory impairment in rat
Status epilepticus causes neuronal damage that is associated with cognitive impairment. The present study examined whether a novel antiepileptic drug, lamotrigine (LTG), alleviates statusExpand
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Chronic elevation of brain GABA levels beginning two days after status epilepticus does not prevent epileptogenesis in rats
Vigabatrin (VGB) treatment is neuroprotective in various models of status epilepticus (SE) and delays the development of kindling via mechanisms that are assumed to relate to the elevation of GABAExpand
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