Detailed NMR, Including 1,1-ADEQUATE, and Anticancer Studies of Compounds from the Echinoderm Colobometra perspinosa
- A. Wright, J. Nielson, C. Liptrot
- ChemistryMarine Drugs
- 12 November 2009
A thorough NMR investigation of rhodoptilometrin was undertaken, finding the in vitro anticancer activity of the original extract was found to be associated with 1, 3 and 5.
Sesquiterpene benzoxazoles and sesquiterpene quinones from the marine sponge Dactylospongia elegans.
- S. Ovenden, J. Nielson, C. Motti
- ChemistryJournal of Natural Products
- 28 January 2011
All compounds isolated from the methanol extract of the marine sponge Dactylospongia elegans were found to have activities in the range 1.8-46 μM and lacked selectivity for tumor versus normal cell lines.
Metachromins U-W: cytotoxic merosesquiterpenoids from an Australian specimen of the sponge Thorecta reticulata.
- S. Ovenden, J. Nielson, C. Motti
- ChemistryJournal of Natural Products
- 22 April 2011
Three new merosesquiterpenoids, metachromins U, V, and W (1-3), were isolated from a specimen of the marine sponge Thorecta reticulata collected off Hunter Island, Tasmania, Australia. Structures of…
A New Diketopiperazine, Cyclo-(4-S-hydroxy-R-proline-R-isoleucine), from an Australian Specimen of the Sponge Stelletta sp. †
- S. Ovenden, J. Nielson, C. Motti
- Chemistry, BiologyMarine Drugs
- 22 November 2011
The isolation and structure elucidation of the diketopiperazine, together with the activity of 1–8 against a panel of human and mammalian cell lines are discussed.
Comosusols A-D and comosone A: cytotoxic compounds from the brown alga Sporochnus comosus.
- S. Ovenden, J. Nielson, D. Tapiolas
- BiologyJournal of Natural Products
- 24 February 2011
Bioassay-guided fractionation of extracts of the brown alga Sporochnus comosus led to the isolation of five new compounds, comosUSols A-D (3-6) and comosone A (7), which were elucidated using standard one- and two-dimensional NMR techniques, as well as comparison with literature values.
Callophycin A, a cytotoxic tetrahydro-β-carboline from the red alga Callophycus oppositifolius
- S. Ovenden, J. Nielson, C. Motti
- Biology
- 15 June 2011
Update of Spectroscopic Data for 4-Hydroxydictyolactone and Dictyol E Isolated from a Halimeda stuposa — Dictyota sp. Assemblage †
- S. Ovenden, J. Nielson, C. Motti
- ChemistryMolecules
- 1 March 2012
The methanol extract of an assemblage of Halimeda stuposa and a Dictyota sp., yielded three natural products characteristic of Dictyota sp., and one of Halimeda sp. These included the xenicane…
A Great Barrier Reef Sinularia sp. Yields Two New Cytotoxic Diterpenes
- A. Wright, J. Nielson, D. Tapiolas, C. Liptrot, C. Motti
- ChemistryMarine Drugs
- 31 July 2012
The methanol extract of a Sinularia sp., collected from Bowden Reef, Queensland, Australia, yielded ten natural products. These included the new nitrogenous diterpene…
A hands on model of skeletal muscle reflexes, tone and innervation
- J. Nielson, Helena Carvalho
- Education
- 1 April 2013
Neuroscience is rapidly advancing field and a large body of information is becoming available. The complexity of these topics can create misconceptions and lead students to feel overwhelmed in their…