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Prediction of O-glycosylation of mammalian proteins: specificity patterns of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase.
TLDR
The context of the sites showed a high abundance of proline, serine and threonine extending far beyond the previously reported region covering positions -4 through +4 relative to the glycosylated residue, and no simple consensus-like rule could be deduced for the complex glycosYLation sequence acceptor patterns.
Non-adherence to anti-hypertensive medication in low- and middle-income countries: a systematic review and meta-analysis of 92443 subjects
TLDR
A systematic review of studies published between 1 January 2000 and 31 August 2015 demonstrated considerable variation of non-adherence to anti-hypertensive medication in low- and middle-income countries depending on the methods used to estimate non- adherence.
Severe acquired immunodeficiency in European homosexual men.
TLDR
Danish homosexual men who present with fever of unknown origin, opportunistic infections, or Kaposi's sarcoma must also be suspected in European homosexual men, where cases of severe acquired immunodeficiency have been reported.
Resistance to V3-directed neutralization caused by an N-linked oligosaccharide depends on the quaternary structure of the HIV-1 envelope oligomer.
TLDR
Treatment of virion preparations with detergent exposed the C-terminal D7324 epitope, which is inaccessible on virion-associated gp120 but readily accessible on monomeric, soluble gp120, and the NEA-9205 epitope was readilyaccessible on monomersic gp120 regardless of the presence of the 306N-glycan.
Temporal relation of antigenaemia and loss of antibodies to core antigens to development of clinical disease in HIV infection.
TLDR
Both antigenaemia and the disappearance of antibodies to the core protein were associated with development of the acquired immune deficiency syndrome (AIDS) or AIDS related complex and depletion of CD4 cells.
Survival differences in European patients with AIDS, 1979–89
TLDR
Improved survival in recent years was observed for patients with a variety of manifestations used to define AIDS but was significant only for patients diagnosed with Pneumocystis carinii pneumonia, and survival seems to vary within Europe, being shorter in southern than central and northern Europe.
The influence of HTLV‐III infection on the natural history of hepatitis B virus infection in male homosexual HBsAg carriers
TLDR
Infection with HTLV‐III may extend the period of active viral replication or even reactivate hepatitis B virus replication and seems to diminish inflammatory disease activity in chronic HBsAg carriers.
Autologous HIV‐1 Neutralizing Antibodies: Emergence of Neutralization‐Resistant Escape Virus and Subsequent Development of Escape Virus Neutralizing Antibodies
TLDR
The delay in appearance of neutralizing antibodies to the dominant viral strain at any time in the patient and the emergence of neutralization resistant escape virus may be part of the explanation of the apparent failure of the immune system to control HIV infection.
Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts.
TLDR
Lower numbers of naive CD4(+) cells and reduced thymic output in HIV-negative infants of HIV-positive mothers may be due to impaired progenitor cell function.
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