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Effector and regulatory mechanisms in allergic contact dermatitis
TLDR
ACD should be considered as a breakdown of the skin immune tolerance to haptens, and the nature, the mode and the site of action of the regulatory T cells that control the skin inflammation are addressed with the aim of developing new strategies of tolerance induction in allergic patients. Expand
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12.
TLDR
It is proposed that the sustained CXCR4 activity in patient cells accounts for the immune-hematologic clinical manifestations and the profusion of warts characteristic of the WHIM syndrome. Expand
Detection and quantification of drug‐specific T cells in penicillin allergy
TLDR
It is confirmed that drug‐induced MPE is associated with the presence of specific T cells in blood and further suggest that the IFN‐γ ELISPOT is a sensitive assay which could improve the diagnosis of betalactam allergy. Expand
Intradermal, epidermal and transcutaneous vaccination: from immunology to clinical practice
TLDR
The most widely accepted paradigm explaining the efficacy of cutaneous immunization is reviewed and recent research suggesting where this paradigm may need some refinement is highlighted. Expand
Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells.
TLDR
It is shown that a population of CD4(+)CD25(+)FoxP3(+) T cells upregulates ICOS on in vivo sensitization and specifically suppresses hapten-reactive CD8(+) T cells both in vivo and in vitro. Expand
Major histocompatibility complex class I‐restricted CD8+ T cells and class II‐restricted CD4+ T cells, respectively, mediate and regulate contact sensitivity to dinitrofluorobenzene
TLDR
Data clearly demonstrate that class I‐restricted CD8+ T cells are sufficient for the induction of CS to DNFB, and further support the idea that MHC class II‐ restricted CD4-restricted T cells down‐regulate this inflammatory response. Expand
Cytotoxicity Is Mandatory for CD8+ T Cell–mediated Contact Hypersensitivity
TLDR
In vivo and in vitro studies showed that the hapten-specific CTL activity was exclusively mediated by MHC class I–restricted CD8+ T cells which could use either the perforin or the Fas/FasL pathway for their lytic activity, indicating cytotoxic T lymphocytes could also mediate harmful delayed-type hypersensitivity reactions. Expand
[Pathogenesis of atopic dermatitis].
TLDR
The ongoing studies on animal models of AD will no doubt permit rapid progression in knowledge of the mechanisms involved in the origin of the disease and the reasons for its progressive increase in frequency. Expand
Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation.
TLDR
Data show that naturally occurring CD4+CD25+ T cells are instrumental for orally induced tolerance and are key actors for the control of antigen-specific CD8+ T-cell effectors mediating skin inflammation. Expand
IgE autoantibodies directed against the major bullous pemphigoid antigen in patients with a severe form of pemphigoid.
TLDR
Results suggest that IgE-dependent mechanisms could participate in the constitution of the lesions in BP. Expand
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