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The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study.
TLDR
Type or intensity of 14 months of treatment for ADHD in childhood does not predict functioning 6 to 8 years later, and early ADHD symptom trajectory regardless of treatment type is prognostic, implying that children with behavioral and sociodemographic advantage, with the best response to any treatment, will have the best long-term prognosis.
DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents.
TLDR
The results support the decision to subdivide the heterogeneous category of DSM-III-R attention deficit hyperactivity disorder into three subtypes and the resulting DSM-IV definition appears to be somewhat less biased toward the symptom pattern typical of elementary school boys.
Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders.
TLDR
The literature supports considerable comorbidity of attention deficit hyperactivity disorder with conduct disorder, oppositional defiant disorder, mood disorders, anxiety disorders, learning disabilities, and other disorders, such as mental retardation, Tourette's syndrome, and borderline personality disorder.
Once-Daily Atomoxetine Treatment for Children and Adolescents With Attention Deficit Hyperactivity Disorder: A Randomized, Placebo-Controlled Study
TLDR
Once-daily administration of atomoxetine is an effective treatment for children and adolescents with attention deficit hyperactivity disorder (ADHD) as assessed by investigator, parent, and teacher ratings.
Symptom profiles in children with ADHD: effects of comorbidity and gender.
OBJECTIVE To examine ratings and objective measures of attention-deficit/hyperactivity disorder (ADHD) symptoms to assess whether ADHD children with and without comorbid conditions have equally high
Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): Implications and Applications for Primary Care Providers
TLDR
Primary analyses revealed that Comb had a significant incremental effect over MedMgt (with a small effect size for this comparison) when categorical indicators of excellent response and when composite outcome measures were used.
Observed Classroom Behavior of Children with ADHD: Relationship to Gender and Comorbidity
TLDR
Elevated rates of ADHD behaviors were also observed in children with comorbid DBD, indicating that these behaviors are truly present and suggesting that reports of higher ADHD ratings in this subgroup are not simply a consequence of negative halo effects and rater biases.
3-year follow-up of the NIMH MTA study.
TLDR
By 36 months, the earlier advantage of having had 14 months of the medication algorithm was no longer apparent, possibly due to age-related decline in ADHD symptoms, changes in medication management intensity, starting or stopping medications altogether, or other factors not yet evaluated.
Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder.
TLDR
Depressed dopamine activity in caudate and preliminary evidence in limbic regions in adults with ADHD that was associated with inattention and with enhanced reinforcing responses to intravenous methylphenidate suggest that dopamine dysfunction is involved with symptoms of inatt attention but may also contribute to substance abuse comorbidity in ADHD.
Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls.
TLDR
Preliminary support is provided to the hypothesis that ADHD is associated with early-appearing and enduring subcortical dysfunction, while recovery over the course of development isassociated with improvements in executive control functions.
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