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Free and albumin-bound bilirubin are efficient co-antioxidants for alpha-tocopherol, inhibiting plasma and low density lipoprotein lipid peroxidation.
Results show that bilirubin inhibits oxidation of LDL lipids initiated within the lipoprotein core and indicate that this activity is mediated by interaction of the pigment with LDL's alpha-tocopherol. Expand
The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.
Evidence highlighting the role of mitochondria as drivers of elevated ROS production during malignant transformation and hence, their potential as targets for cancer therapy is focused on. Expand
Reactive oxygen species are generated by the respiratory complex II – evidence for lack of contribution of the reverse electron flow in complex I
It is shown that the CII Q site inhibitor thenoyltrifluoroacetone (TTFA) blocks succinate + rotenone‐driven ROS production, whereas the CIII Qo inhibitor stigmatellin has no effect, indicating that CII, not CIII, is the ROS‐producing site. Expand
Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA.
Findings indicate horizontal transfer of mtDNA from host cells in the tumor microenvironment to tumor cells with compromised respiratory function to re-establish respiration and tumor-initiating efficacy and suggest pathophysiological processes for overcoming mtDNA damage. Expand
Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements
This work shows that the proapoptotic activity of α‐TOS in hematopoietic and cancer cell lines involves inhibition of protein kinase C (PKC), since phorbol myristyl acetate prevented α-TOS‐triggered apoptosis. Expand
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.
  • T. Weber, M. Lu, +13 authors J. Neuzil
  • Medicine
  • Clinical cancer research : an official journal of…
  • 1 March 2002
Vitamin E succinate is a potent and highly specific anticancer agent and/or adjuvant of considerable therapeutic potential and exerted a cooperative proapoptotic activity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in suppression of tumor growth in vivo. Expand
The European perspective on vitamin E: current knowledge and future research.
The scientists agreed that the functions of vitamin E were underestimated if one considered only its antioxidative properties, and future research on this essential vitamin should focus on what makes it essential for humans, why the body apparently utilizes alpha-tocopherol preferentially, and what functions other forms of Vitamin E have. Expand
Cosupplementation with coenzyme Q prevents the prooxidant effect of alpha-tocopherol and increases the resistance of LDL to transition metal-dependent oxidation initiation.
It is demonstrated that oral supplementation with alpha-TOH alone results in LDL that is more prone to oxidation initiation, whereas cosupplementation with coenzyme Q not only prevents this prooxidant activity of vitamin E but also provides the lipoprotein with increased resistance to oxidation. Expand
Association of MiR-126 with Soluble Mesothelin-Related Peptides, a Marker for Malignant Mesothelioma
Levels of miR-126 in serum, and its levels in patients' serum in association with a specific marker of MPM, SMRPs, correlate with subjects at high risk to develop MPM. Expand
α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II
It is proposed that α-TOS displaces UbQ in CII causing electrons generated by SDH to recombine with molecular oxygen to yield ROS, highlighting CII, a known tumour suppressor, as a novel target for cancer therapy. Expand