• Publications
  • Influence
Alterations in connexin expression in the bladder of patients with urge symptoms
TLDR
To compare the formation of gap junctions between detrusor smooth muscle cells in situ and the distribution of connexin (Cx)40, Cx43 and Cx45 expressions in bladder biopsies from a control group and from patients with urge symptoms, it is suggested that alterations of which may be involved in the causes of lower urinary tract symptoms are investigated.
Palmitate Induced IL-6 and MCP-1 Expression in Human Bladder Smooth Muscle Cells Provides a Link between Diabetes and Urinary Tract Infections
TLDR
Induction of IL-6 in human bladder smooth muscle cells by fatty acids may represent a pathogenetic factor underlying the higher frequency and persistence of urinary tract infections in patients with metabolic diseases.
Prediction of Muscle-invasive Bladder Cancer Using Urinary Proteomics
TLDR
Use of urinary peptides seems promising in estimating the probability a patient harbors muscle-invasive urothelial bladder cancer, and may also shed novel insights into the biology of bladder tumor progression not obtainable by other methods.
TGF-beta1 inhibits Cx43 expression and formation of functional syncytia in cultured smooth muscle cells from human detrusor.
TLDR
The view that TGF-beta1 is involved in the pathophysiology of urinary bladder dysfunction is supported, with a significant down regulation of connexin 43 by T GF- beta1 in cultured hBSMCs.
Seminal Plasma as a Source of Prostate Cancer Peptide Biomarker Candidates for Detection of Indolent and Advanced Disease
TLDR
Seminal plasma represents a robust source of potential peptide makers for primary PCa diagnosis and warrants further prospective validation to confirm the diagnostic potential of identified seminal biomarker candidates.
Individual receptor profiling as a novel tool to support diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC)
TLDR
M2, P 2X1, P2X2 and H1 were significantly upregulated in BPS/IC patients, and H2 was occasionally highly overexpressed, implying posttranslational mechanisms being responsible for the altered receptor expressions.
Increased sensitivity to 4-chloro-m-cresol and caffeine in primary myotubes from malignant hyperthermia susceptible individuals carrying the ryanodine receptor 1 Thr2206Met (C6617T) mutation.
TLDR
Myotubes derived from individuals carrying the RyR1 Thr2206Met (C6617T) mutation have an abnormal response of the intracellular calcium concentration to 4-chloro-m-cresol and to caffeine.
Identification of Key Biomarkers in Bladder Cancer: Evidence from a Bioinformatics Analysis
TLDR
The present study highlights an up to now unrecognized possible role of CASQ2 in cancer (BCa), and suggests that CRYAB may also be a candidate biomarker in BCa.
Intravesical treatments of bladder pain syndrome/interstitial cystitis
TLDR
Overall, botulinum neurotoxin A injection, intravesical sodium hyaluronate instillation and DMSO instillation seem to be the best-performing treatments, with response rates of 79%, 76% and 75%, respectively, and can be used effectively as second-line or third-line therapies for BPS/IC.
...
1
2
3
4
5
...