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Caffeine and related methylxanthines: possible naturally occurring pesticides.
Data suggest that methylxanthines may function as natural insecticides and that phosphodiesterase inhibitors, alone or in combination with other compounds, may be useful in insect control. Expand
Nitrovasodilators as a new class of ocular hypotensive agents.
  • J. Nathanson
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1 March 1992
Tonographic studies showed that topically applied nitroglycerin and hydralazine increased the facility (decreased the resistance) of aqueous humor leaving the eye and indicate that tophetically applied nitrovasodilators can effectively lower intraocular pressure at doses which have little effect on systemic blood pressure. Expand
Nitric oxide, cGMP, and hormone regulation of active sodium transport.
Evidence is reported that NO, produced in response to various hormones and cytokines, can effect long-term alterations in the activity of the membrane sodium pump, which represents a mechanism for hormonal modulation of ion gradients not only in kidney but also in other organs, including brain, where NO and cGMP play a prominent role in cellular function. Expand
Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye.
The human outflow pathway and CM are enriched sites of NO synthesis, suggesting that one possible role for NO in the anterior segment may be to modulate outflow resistance either directly at the level of the trabecular meshwork, Schlemm's canal and collecting channels, or indirectly through alteration in the tone of the longitudinal CM. Expand
Alterations of ocular nitric oxide synthase in human glaucoma.
Investigating the possibility that alterations in NO or defects in NO-synthesizing tissues might exist in glaucomatous eyes indicate that NO has relevance to the course, treatment, or both, or some forms of this disease. Expand
Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys.
The capacity for topically applied NTG and HZN to reduce IOP in the living primate eye is demonstrated and it is suggested that, at certain drug doses, but not others, the IOP reduction may be mediated, in part, by an action on the outflow apparatus. Expand
Cocaine as a naturally occurring insecticide.
It is demonstrated that cocaine exerts insecticidal effects at concentrations which occur naturally in coca leaves, and that octopamine transporters may be useful sites for targeting pesticides with selectivity toward invertebrates. Expand
Brain barrier tissues: end organs for atriopeptins.
The present experiments show that blood-brain and blood-cerebrospinal fluid barriers contain receptors and second messenger systems for atriopeptins, recently identified cardiac peptides involved in peripheral water regulation, and that atriopes could have therapeutic application to disorders of water balance in the central nervous system. Expand
The cellular Na+ pump as a site of action for carbon monoxide and glutamate: A mechanism for long-term modulation of cellular activity
The data suggest that CO regulates Na,K-ATPase through cGMP and PKG, and that Glu regulates CO through mGluRs, which offers a mechanism by which CO, Glu, and free radicals can exert specific effects on synaptic transmission and more general actions on energy metabolism. Expand
Atrial Natriuretic Factor and Salt Wasting After Aneurysmal Subarachnoid Hemorrhage
A markedly increased atrial natriuretic factor concentration precedes natriuresis in some patients and, with other abnormalities of water handling possibly including a relatively diminished vasopressin concentration, may cause volume depletion. Expand