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Pathogenic Escherichia coli
Few microorganisms are as versatile as Escherichia coli; it can also be a highly versatile, and frequently deadly, pathogen. Expand
Diarrheagenic Escherichia coli
The current level of understanding of the pathogenesis of the diarrheagenic E. coli strains is discussed and how their pathogenic schemes underlie the clinical manifestations, diagnostic approach, and epidemiologic investigation of these important pathogens are described. Expand
Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study
Interventions targeting five pathogens can substantially reduce the burden of moderate-to-severe diarrhoea and suggest new methods and accelerated implementation of existing interventions (rotavirus vaccine and zinc) are needed to prevent disease and improve outcomes. Expand
Bacteria–host communication: The language of hormones
It is shown that an EHEC luxS mutant, unable to produce the bacterial autoinducer, still responds to a eukaryotic cell signal to activate expression of its virulence genes, implying a potential cross-communication between the luxS/AI-3 bacterial QS system and the epinephrine host signaling system. Expand
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany.
The findings suggest that horizontal genetic exchange allowed for the emergence of the highly virulent Shiga-toxin-producing enteroaggregative E. coli O104:H4 strain that caused the German outbreak, and highlight the way in which the plasticity of bacterial genomes facilitates the emerged of new pathogens. Expand
The great escape: structure and function of the autotransporter proteins.
The autotransporters, a family of secreted proteins from Gram-negative bacteria, possess an overall unifying structure comprising three functional domains: the amino-terminal leader sequence, theExpand
Characterization of Pic, a Secreted Protease ofShigella flexneri and EnteroaggregativeEscherichia coli
Functional analysis of the Pic protein implicates this factor in mucinase activity, serum resistance, and hemagglutination, suggesting that Pic may be a multifunctional protein involved in enteric pathogenesis. Expand
Proteomic and microarray characterization of the AggR regulon identifies a pheU pathogenicity island in enteroaggregative Escherichia coli
Using proteomic and microarray analysis, it is identified for the first time that AggR activates the expression of chromosomal genes, including 25 contiguous genes (aaiA–Y), which are localized to a 117 kb pathogenicity island (PAI) inserted at pheU. Expand
Enteroaggregative Escherichia coli.
The pathogenesis of EAEC infection is not well understood, but a model can be proposed in which EAEC adhere to the intestinal mucosa and elaborate enterotoxins and cytotoxin, which result in secretory diarrhea and mucosal damage. Expand
Detection of an adherence factor of enteropathogenic Escherichia coli with a DNA probe.
A DNA probe to detect genes conferring localized adherence of enteropathogenic Escherichia coli to Hep-2 cells was evaluated by using E. coli isolates from the stools of Peruvian infants with and without diarrhea and revealed that Hep- 2 adherence was more frequent in some O serogroups of EPEC than in others. Expand