Universal quantitative NMR analysis of complex natural samples.
Dentin Biomodification Potential Depends on Polyphenol Source
- T. Aguiar, C. Vidal, A. Bedran-Russo
- Chemistry, MedicineJournal of dentistry research
- 26 February 2014
Findings provide clear evidence that the dentin bioactivities of PACs are source dependent, resulting from a combination of concentration and specific chemical constitution of the complex PAC mixtures.
Importance of Purity Evaluation and the Potential of Quantitative 1H NMR as a Purity Assay
This study reviews underlying concepts, provides a framework for standard qHNMR purity assays, and shows how adequate accuracy and precision are achieved for the intended use of the material.
Chlorinated coumarins from the polypore mushroom Fomitopsis officinalis and their activity against Mycobacterium tuberculosis.
An EtOH extract of the polypore mushroom Fomitopsis officinalis afforded two new naturally occurring chlorinated coumarins, which were identified as the previously synthesized compounds 6-chloro-4-phenyl-2H-chromen-2-one and ethyl 6- chloro-1-oxo-3-carboxylate, which revealed a narrow spectrum of activity with lowest MICs against the Mycobacterium tuberculosis complex.
Discovery and characterization of the tuberculosis drug lead ecumicin.
Determination of absolute configuration and unambiguous structural confirmation were carried out by X-ray crystallography and Marfey's analysis and the resulting two possible planar structures were distinguished by LC-MS.
Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins.
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba
- J. Napolitano, D. Lankin, Shao-Nong Chen, G. Pauli
- ChemistryMagnetic resonance in chemistry : MRC
- 1 August 2012
The complete and unambiguous 1H NMR assignments of ten marker constituents of Ginkgo biloba are described and a revised set of 1HNMR parameters for all ten phytoconstituents was assembled.
The tandem of full spin analysis and qHNMR for the quality control of botanicals exemplified with Ginkgo biloba.
This study demonstrates how a combination of computer-aided spectral analysis and 1D quantitative ¹H NMR spectroscopy (qHNMR) generates the analytical foundation for innovative means of simultaneously identifying and quantifying botanical markers in complex mixtures.
HiFSA fingerprinting applied to isomers with near-identical NMR spectra: the silybin/isosilybin case.
This study demonstrates how regio- and diastereo-isomers with near-identical NMR spectra can be distinguished and unambiguously assigned using quantum mechanical driven (1)H iterative Full Spin…
On the configuration of five-membered rings: a spin-spin coupling constant approach.
- J. Napolitano, J. Gavín, Celina García, M. Norte, J. J. Fernández, A. Daranas
- 27 May 2011
This approach can be easily used to analyze different five-membered rings, such as oxolanes, cyclopentanes, furanosides and pyrrolidines, and their relative configuration can be determined without the need for making further conformational considerations.