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Acidosis stimulates nitric oxide production and lung damage in rats.
In this model, moderate acidosis causes increases in NO, hypotension, and lung inflammation, which has profound implications on the role of acidosis on NO production and lung injury during sepsis. Expand
Hyperbaric Oxygenation Therapy Alleviates Chronic Constrictive Injury–Induced Neuropathic Pain and Reduces Tumor Necrosis Factor-Alpha Production
CCI induced significant cold and mechanical allodynia as measured after CCI on days 4 and 7 and the alleviated neuropathic pain may be associated with reduced production of TNF-&agr; and/or IL-1&bgr;, which was verified by Western blot analysis. Expand
Anorexia in space and possible etiologies: an overview.
The laboratories used the antiorthostatic tail-suspension technique to successfully mimic some of these anorexia-related stress responses and to directly demonstrate the role of 5-HT in microgravity-related decreased food intake and delayed gastric emptying, which may lead to a quantitative enhancement of physiologic well-being and performance status. Expand
Hyperbaric Oxygenation Ameliorates Indomethacin-Induced Enteropathy in Rats by Modulating TNF-α and IL-1β Production
The effect of hyperbaric oxygenation (HBO2) was investigated in a rat model of indomethacin-induced enteropathy. Enteropathy was induced by two subcutaneous injections of indomethacin (7.5 mg/kg) 24Expand
Effects of a phorbol ester and isoquinoline sulfonamides on rabbit parietal cell function.
The results indicate that TPA-induced inhibition of secretagogue-stimulated AP uptake in PC is presumably mediated by activation of PKC. Expand
TNF-α modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis
TNF-α plays an early pro-inflammatory role in indomethacin-induced jejunoileitis and down-regulation of NOx by PDE inhibitors, TNF-Ab, or HBO2 suggests that T NF-α modulates iNOS expression. Expand
Beneficial effect of hyperbaric oxygen pretreatment on lipopolysaccharide‐induced shock in rats
1. We investigated the effect of hyperbaric oxygenation (HBO2) pretreatment on the production of exhaled nitric oxide (ENO) and the expression of lung inducible nitric oxide synthase (iNOS) byExpand
Central mechanisms involved with catabolism
The net effect is anorexia, with the inhibition of food intake, body weight loss, delayed gastric emptying and functions, the stimulation of gluconeogenesis, glycogenolysis and ketogenesis as sources of metabolic fuel, which if unabated leads ultimately to cachexia. Expand
Aspirin potentiates prestimulated acid secretion and mobilizes intracellular calcium in rabbit parietal cells.
Results indicate that aspirin acts at a site beyond the adenylate cyclase/cAMP system and before the proton pump, presumably by releasing Ca2+ from an IP3-independent intracellular storage pool and by inhibiting PGE2 generation. Expand
Hyperbaric oxygenation ameliorates indomethacin-induced enteropathy in rats by modulating TNF-alpha and IL-1beta production.
The data suggest that HBO2 treatment has a beneficial effect on indomethacin-induced enteropathy and this effect is possibly mediated by decreased production of TNF-alpha and IL-1beta. Expand