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Dentin biomodification: strategies, renewable resources and clinical applications.
This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications. Expand
Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-kappaB pathway in LPS-stimulated
The findings of the present study indicate that zedoarondiol inhibits iNOS, COX-2, and pro-inflammatory cytokine expressions by suppressing the phosphorylations of IKK and MAPKs, and by subsequently inactivating the NF-kappaB pathway. Expand
Identification of a new naphthalene and its derivatives from the bulb of eleutherine americana with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
  • A. Han, H. Min, +6 authors E. Seo
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • 1 September 2008
A new naphthoquinone was isolated from the bulb of Eleutherine americana MERR together with two known compounds, eleutherinol and 1,5-dihydroxy-3-methylanthraquinone which were found in this species for the first time. Expand
Cytotoxic and antineoplastic activity of timosaponin A-III for human colon cancer cells.
Treatment with compound 1 for four weeks significantly suppressed tumor growth in athymic nude mice bearing HCT-15 cells, without any overt toxicity. Expand
Identification of a new cytotoxic biflavanone from Selaginella doederleinii.
A new biflavanone, 2,2'',3,3''-tetrahydrorobustaflavone 7,4',7''-trimethyl ether was isolated from the whole plant of Selaginella doederleinii HIERON and used as the cytotoxic constituents against the three human cancer cell lines, HCT, NCI-H358, and K562. Expand
Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia.
Psoralidin is able to mimic the binding interactions of E2, and thus, it could act as an ER agonist in the cellular environment, as shown by chromatin immunoprecipitation assay results. Expand
Mimicking the hierarchical functions of dentin collagen cross-links with plant derived phenols and phenolic acids.
Findings reveal that the molecular weight of polyphenols have a determinant effect on their interaction with type I collagen and modulates the mechanism of cross-linking at the molecular, intermolecular, and inter-microfibrillar levels. Expand
Subtle Chemical Shifts Explain the NMR Fingerprints of Oligomeric Proanthocyanidins with High Dentin Biomodification Potency.
These newly characterized chemical shift differences in ppb are small but diagnostic measures of dynamic processes inherent to the OPAC pharmacophores and can help augment the understanding of nanometer-scale intermolecular interactions in biomodified dentin macromolecules. Expand
Diarylheptanoids from the seeds of Alpinia katsumadai as heat shock factor 1 inducers.
Seven new diarylheptanoids, (-)-(R)-4″-hydroxyyashabushiketol, were isolated from the EtOAc extract of the seeds of Alpinia katsumadai together with three known compounds, alpinnanin B (7), epicalyxin H (9), and calyx in H (10) without cellular cytotoxicity, suggesting a possible application of these compounds as HSP inducers. Expand
Biostability of the Proanthocyanidins-Dentin Complex and Adhesion Studies
Standardized OPAC mixtures provide a new mechanism of adhesion to type I collagen–rich tissues that does not rely on hydrophilic monomers and involves physicochemical modifications to the dentin matrix, reduced tissue biodegradation, and bridging to methacrylate resins. Expand