• Publications
  • Influence
Developmental pharmacokinetics.
The advances in developmental pharmacokinetics during the past decade reside with an enhanced understanding of the influence of growth and development on drug absorption, distribution, metabolism,Expand
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Rising opioid prescribing in adult U.S. emergency department visits: 2001-2010.
OBJECTIVES The objective was to describe trends in opioid and nonopioid analgesia prescribing for adults in U.S. emergency departments (EDs) over the past decade. METHODS Data from the NationalExpand
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Developmental Changes in Pharmacokinetics and Pharmacodynamics
Effective drug therapy to optimally influence disease requires an understanding of a drug's pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In pediatrics, age is a continuumExpand
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Developmental pharmacology.
Understanding the pharmacokinetics and pharmacodynamics of drugs used in psychopharmacology across the pediatric age spectrum from infants to adolescents represents a major challenge for clinicians.Expand
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Trends in Prescription Opioid Use in Pediatric Emergency Department Patients
Objective In recent years, there has been increased emphasis on treating pain in emergency departments (EDs), coinciding with mounting concerns regarding the abuse potential of prescription opioids.Expand
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Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.
OBJECTIVES To evaluate the safety and tolerability of treatment with levetiracetam and determine the trough levels of levetiracetam in patients with traumatic brain injury (TBI) who are at high riskExpand
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Neonatal clinical pharmacology.
Effective and safe drug administration in neonates should be based on integrated knowledge on the evolving physiological characteristics of the infant who will receive the drug and theExpand
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Benzodiazepine Prescribing in Older Adults in U.S. Ambulatory Clinics and Emergency Departments (2001-10).
OBJECTIVES To assess trends in benzodiazepine use from 2001 to 2010 in older adults in U.S. ambulatory clinics and emergency departments (EDs). DESIGN Retrospective analysis. SETTING 2001 to 2010Expand
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Trends in pregnancy labeling and data quality for US-approved pharmaceuticals.
OBJECTIVE Over the past decades, there have been significant efforts in the United States to improve pharmaceutical labeling pertaining to pregnancy. The goal of this study was to describe trends inExpand
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More Codeine Fatalities After Tonsillectomy in North American Children
In 2009 we reported the fatal case of a toddler who had received codeine after adenotonsillectomy for obstructive sleep apnea syndrome. The child was an ultra-rapid metabolizer of cytochrome P4502D6Expand
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