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The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
TLDR
A novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFβ family receptors is defined as blocking the association, phosphorylation, and activation of Smad2. Expand
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.
TLDR
A novel function for MAD-related proteins as intracellular antagonists of the type I kinase domain of TGFbeta family receptors is defined as blocking the association, phosphorylation, and activation of Smad2. Expand
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are
TLDR
Three genes with potential atheroprotective activities manifest a differential response to distinct fluid mechanical stimuli, providing a possible mechanistic link between endothelial gene expression and early events in atherogenesis. Expand
Endothelial Dysfunction, Hemodynamic Forces, and Atherogenesis a
TLDR
It is hypothesized that the selective and sustained expression of certain transcription factors and related “atheroprotective genes” in the endothelial lining of lesion‐protected areas represents a mechanism whereby hemodynamic forces can influence lesion formation and progression. Expand
Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium*
TLDR
SCUBE1 and SCUBE2 define an emerging family of human secreted proteins that are expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis. Expand
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium.
TLDR
Smad6 and Smad7 constitute a novel class of MAD-related proteins, termed vascular MADs, that are induced by fluid mechanical forces and can modulate gene expression in response to both humoral and biomechanical stimulation in vascular endothelium. Expand
Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology.
TLDR
Interestingly, the impact of these risk factors on disease development and progression in the peripheral vasculature are not the same as those in the coronary vessels and may represent an avenue of investigation to explain variations in clinical presentation. Expand
Promoter selection in human mitochondria involves binding of a transcription factor to orientation-independent upstream regulatory elements
TLDR
Functional domains, required for positive transcriptional regulation by mtTF, are identified within both major promoters of human mtDNA through transcription of mutant promoter templates in a reconstituted in vitro system. Expand
Biomechanical activation: an emerging paradigm in endothelial adhesion biology.
TLDR
A perspective on the role of biomechanical forces, alone and in conjunction with humoral stimuli, in modulating the adhesive interactions of vascular endothelium in health and disease is provided. Expand
STRUCTURAL ORGANIZATION OF THE OXIDIZING SIDE OF PHOTOSYSTEM II EXOGENOUS REDUCTANTS REDUCE AND DESTROY THE Mn-COMPLEX IN PHOTOSYSTEMS II MEMBRANES DEPLETED OF THE 17 AND 23 kDa POLYPEPTIDES
Removal of 23 and 17 kDa water-soluble polypeptides from PS II membranes causes a marked decrease in oxygen-evolution activity, exposes the oxidizing side of PS II to exogenous reductantsExpand
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