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Intensive versus conventional glucose control in critically ill patients.
TLDR
In this large, international, randomized trial, it was found that intensive glucose control increased mortality among adults in the ICU: a blood glucose target of 180 mg or less per deciliter resulted in lower mortality than did a target of 81 to 108 mg perDeciliter.
A comparison of albumin and saline for fluid resuscitation in the intensive care unit.
TLDR
In patients in the ICU, use of either 4 percent albumin or normal saline for fluid resuscitation results in similar outcomes at 28 days, with no significant differences between the groups.
Hydroxyethyl starch or saline for fluid resuscitation in intensive care.
TLDR
In patients in the ICU, there was no significant difference in 90-day mortality between patients resuscitated with 6% HES (130/0.4) or saline, however, more patients who received resuscitation with HES were treated with renal-replacement therapy.
Resuscitation fluids.
From the University of New South Wales, the Division of Critical Care and Trauma, George Institute for Global Health, and the Department of Intensive Care Medicine, St. George Hospital — all in
Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units
TLDR
The population incidence and outcome of severe sepsis occurring in adult patients treated in Australian and New Zealand intensive care units (ICUs), and compare with recent retrospective estimates from the USA and UK are determined.
Effect of a Buffered Crystalloid Solution vs Saline on Acute Kidney Injury Among Patients in the Intensive Care Unit: The SPLIT Randomized Clinical Trial.
TLDR
Among patients receiving crystalloid fluid therapy in the ICU, use of a buffered crystalloid compared with saline did not reduce the risk of AKI and main secondary outcomes were incidence of RRT use and in-hospital mortality.
Hypoglycemia and risk of death in critically ill patients.
TLDR
In critically ill patients, intensive glucose control leads to moderate and severe hypoglycemia, both of which are associated with an increased risk of death, and the association exhibits a dose-response relationship and is strongest for death from distributive shock.
Epidemiology and 12-month outcomes from traumatic brain injury in australia and new zealand.
TLDR
In Australia and New Zealand, mortality and favorable neurologic outcomes after TBI were similar to published data before the advent of evidence-based guidelines, suggesting a high incidence of prehospital secondary brain insults and an ageing population may have contributed to these outcomes.
Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
TLDR
Among patients with septic shock undergoing mechanical ventilation, a continuous infusion of hydrocortisone did not result in lower 90‐day mortality than placebo and there were no significant between‐group differences with respect to mortality at 28 days, the rate of recurrence of shock, the number of days alive and out of the ICU, the Recurrence of mechanical ventilation.
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