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Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis
TLDR
Comparison of nilotinib and imatinib inhibition of FMS receptor signaling, macrophage production and osteoclastogenesis shows clear differences in the effects of these drugs on FMS receptors and macrophages. Expand
A randomised, double-blind, placebo-controlled trial of a recombinant version of human α-fetoprotein (MM-093) in patients with active rheumatoid arthritis
TLDR
Evidence of efficacy was observed in the first randomised, controlled trial of MM-093, a recombinant version of human AFP, in patients with RA, suggesting that MM- 093 may have therapeutic potential in RA. Expand
The lactoferrin receptor may mediate the reduction of eosinophils in the duodenum of pigs consuming milk containing recombinant human lactoferrin
TLDR
Immunohistochemistry showed that within the duodenum the LFR localized on the brush border of villi, crypts, and within the lamina propria, which may be a mechanism allowing lactoferrin to directly inhibit eosinophil migration. Expand
Transgenic animal models for the production of human immunocompounds in milk to prevent diarrhea, malnourishment and child mortality: perspectives for the Brazilian Semi-Arid region
TLDR
The proposed research was designed with the rational that the transgenic approach can be used to modify the milk composition of dairy animals to supply milk-borne human immunocompounds (rhLZ, rhLF) and nutrients, which is a unique approach for delivering the potential protective benefits of human milk. Expand